Evidence map›Paper›PMID 30389931›Full record

ArticleNature communications2018

Tissue-resident memory T cells populate the human brain.

Joost Smolders, Kirstin M Heutinck, Nina L Fransen, Ester B M Remmerswaal, Pleun Hombrink, Ineke J M Ten Berge, René A W van Lier, Inge Huitinga, Jörg Hamann

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 261 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
261citing papers in PubMed, 2 pooled it
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

261 citing papers in PubMed, 2 syntheses or guidelines pooled it, 383 citations in OpenAlex.

  1. Pooled it
  2. Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
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  7. Article
  8. Article
  9. Article
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  12. The neuroimmune system and cognition.Nature immunology · 2026
    Review
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  15. Article
  16. Article
  17. PD-1 Inhibits CD4+ TRM-Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Review
  19. Article
  20. Article

201 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Joost SmoldersDepartment of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands. j.smolders@cwz.nl.ORCID http://orcid.org/0000-0001-9766-8661
Kirstin M HeutinckDepartment of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.
Nina L FransenDepartment of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0958-7162
Ester B M RemmerswaalDepartment of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.
Pleun HombrinkDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.
Ineke J M Ten BergeDepartment of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8535-2766
René A W van LierDepartment of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.
Inge HuitingaDepartment of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-4878-8920
Jörg HamannDepartment of Neuroimmunology, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105BA, Amsterdam, The Netherlands. j.hamann@amc.uva.nl.
Netherlands Institute for Neuroscience · NLAmsterdam Neuroscience · NLSanquin · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most tissues are populated by tissue-resident memory T cells (T

Indexed as

Immunologic MemoryAgedAged, 80 and overAntigens, CDBiomarkersBrainCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCTLA-4 AntigenFemaleHumansIntegrin alpha ChainsMaleMiddle AgedOrgan SpecificityProgrammed Cell Death 1 Receptoralpha E integrinsAntigens, CDBiomarkersCTLA-4 AntigenIntegrin alpha ChainsPDCD1 protein, humanProgrammed Cell Death 1 ReceptorTranscription Factors

Identifiers

PMID30389931
PMCPMC6214977
OpenAlexW2899073628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.