Evidence map›Paper›PMID 30389925›Full record

ArticleNature communications2018

Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.

Mauricio S Caetano, Maya Hassane, Hieu T Van, Emmanuel Bugarin, Amber M Cumpian, Christina L McDowell, Carolina Gonzalez Cavazos, Huiyuan Zhang, Shanshan Deng, Lixia Diao and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 4 countries.

Mauricio S CaetanoDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Maya HassaneDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, 11072020, Lebanon.
Hieu T VanDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Emmanuel BugarinDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.ORCID http://orcid.org/0000-0002-2069-3663
Amber M CumpianDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Christina L McDowellDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Carolina Gonzalez CavazosDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Huiyuan ZhangDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Shanshan DengDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Lixia DiaoDepartment of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Jing WangDepartment of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Scott E EvansDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Carmen BehrensDepartment of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Ignacio I WistubaDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.
Susan A W FuquaLester and Sue Smith Breast Center, Baylor College of Medicine, Houston, 77030, TX, USA.
Huang LinDepartment of Biostatistics, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, 15232, PA, USA.
Laura P StabileDepartment of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, 15232, PA, USA.
Stephanie S WatowichDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA.ORCID http://orcid.org/0000-0003-1969-659X
Humam KadaraDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, 11072020, Lebanon. hk94@aub.edu.lb.
Seyed Javad MoghaddamDepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, 77030, TX, USA. smoghadd@mdanderson.org.ORCID http://orcid.org/0000-0002-5350-307X
The University of Texas MD Anderson Cancer Center · USUPMC Hillman Cancer Center · USAmerican University of Beirut · LBBaylor College of Medicine · US

Funding

Epithelial mechanisms of inducible resistance to AML-associated pneumoniaR01HL117976 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI EVANS, SCOTT E. · 2014 to 2018
$2.0M
(PQ1) Progression of the airway field of injury to Kras mutant lung cancerR01CA205608 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KADARA, HUMAM, SCHEET, PAUL A · 2016 to 2019
$1.4M
NCI NIH HHS R01 CA205608NHLBI NIH HHS R01 HL117976
6 · The paper itself

Abstract

Lung adenocarcinomas (LUADs) with mutations in the K-ras oncogene display dismal prognosis. Proinflammatory and immunomodulatory events that drive development of K-ras mutant LUAD are poorly understood. Here, we develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout (LR/Stat3

Indexed as

Sex CharacteristicsSignal TransductionAnimalsEpithelial CellsFemaleGene DeletionInterleukin-6Lung NeoplasmsMaleMiceModels, BiologicalMutationNeutrophilsProto-Oncogene Proteins p21(ras)Receptors, EstrogenSTAT3 Transcription FactorHras protein, mouseInterleukin-6Proto-Oncogene Proteins p21(ras)Receptors, EstrogenSTAT3 Transcription Factor

Identifiers

PMID30389925
PMCPMC6214980
OpenAlexW2899055178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.