Evidence map›Paper›PMID 30389909›Full record

ArticleCell death & disease2018

Estrogen receptor β upregulated by lncRNA-H19 to promote cancer stem-like properties in papillary thyroid carcinoma.

Mei Li, Hui-Fang Chai, Fei Peng, Yu-Ting Meng, Li-Zhi Zhang, Lin Zhang, Hong Zou, Qi-Lan Liang, Man-Man Li, Kai-Ge Mao and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. The Changing Face ofFrontiers in surgery · 2020
    Pooled it
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  4. Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026
    Review
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  7. Myeloid-derived suppressor cells modulation in the context of tumor microenvironment for gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 2 countries.

Mei LiThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Hui-Fang ChaiThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Fei PengThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Yu-Ting MengThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Li-Zhi ZhangDepartment of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Lin ZhangDalian Municipal Women And Children's Medical Center, Dalian, China.
Hong ZouThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Qi-Lan LiangThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Man-Man LiThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Kai-Ge MaoThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Dong-Xu SunThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Meng-Ying TongThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Zi-Qian DengThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Zhi-Jie HouThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Yi ZhaoThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Jia LiThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Xiao-Chao WangThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Sha-Sha LvThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Qing-Qing ZhangDepartmemt of Pathology, Dalian Medical University, Dalian, China.
Xiao YuDepartmemt of Pathology, Dalian Medical University, Dalian, China.
Eric W-F LamDepartment of Surgery and Cancer, Imperial College London, London, W12 0NN, UK.ORCID http://orcid.org/0000-0003-1274-3576
Quentin LiuThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. liuq9@mail.sysu.edu.cn.
Xiao-Nan CuiThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. cxn23@sina.com.
Jie XuThe First Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. xujie@dmu.edu.cn.
Dalian Medical University · CNSun Yat-sen University · CNImperial College London · GB

Funding

Cancer Research UK 12011Medical Research Council MR/N012097/1
6 · The paper itself

Abstract

Estrogen receptor β (ERβ) plays critical roles in thyroid cancer progression. However, its role in thyroid cancer stem cell maintenance remains elusive. Here, we report that ERβ is overexpressed in papillary thyroid cancer stem cells (PTCSCs), whereas ablation of ERβ decreases stemness-related factors expression, diminishes ALDH

Indexed as

Gene Expression Regulation, NeoplasticAldehyde Dehydrogenase 1 FamilyAnimalsAntineoplastic AgentsAspirinCarcinogenesisCell Line, TumorCell ProliferationEstradiolEstrogen Receptor betaFeedback, PhysiologicalFemaleHeterograftsHumansMiceMice, Inbred BALB CAldehyde Dehydrogenase 1 FamilyAntineoplastic AgentsAspirinEstradiolEstrogen Receptor betaH19 long non-coding RNAMicroRNAsMIRN3126 microRNA, humanRNA, Long Noncoding

Identifiers

PMID30389909
PMCPMC6214949
OpenAlexW2898975775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.