Evidence map›Paper›PMID 30389852›Full record

ArticleDevelopment (Cambridge, England)2018

Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal.

Rebecca P Kim-Yip, Todd G Nystul

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  5. Life science alliance · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rebecca P Kim-YipCenter for Reproductive Sciences, Departments of Anatomy and OB/GYN-RS, University of California, San Francisco, CA 94143-0452, USA.ORCID 0000-0002-6250-2394
Todd G NystulCenter for Reproductive Sciences, Departments of Anatomy and OB/GYN-RS, University of California, San Francisco, CA 94143-0452, USA todd.nystul@ucsf.edu.ORCID 0000-0002-6250-2394
University of California, San Francisco · US

Funding

GENETICS OF EUCARYOTIC AND PROCARYOTIC ORGANISMST32GM007810 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH, NARLIKAR, GEETA J · 1985 to 2020
$15.1M
REPRODUCTIVE ENDOCRINOLOGYT32HD007263 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MELLON, SYNTHIA H · 1985 to 2023
$4.1M
Modeling epithelial stem cell competition in a dynamic Drosophila ovarian nicheR01GM097158 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NYSTUL, TODD · 2011 to 2019
$3.1M
Spinning disk confocal / FRAP microscope for quantitative live cell imagingS10RR026758 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTMANN, TORSTEN · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026758NICHD NIH HHS T32 HD007263NIGMS NIH HHS R01 GM097158NIGMS NIH HHS T32 GM007810
6 · The paper itself

Abstract

Adult stem cell niche boundaries must be precisely maintained to facilitate the segregation of stem cell and daughter cell fates. However, the mechanisms that govern this process in epithelial tissues are not fully understood. In this study, we investigated the relationship between two signals, Wnt and EGFR, that are necessary for self-renewal of the epithelial follicle stem cells (FSCs) in the

Indexed as

Cell Self RenewalAnimalsDrosophila melanogasterDrosophila ProteinsEpidermal Growth FactorErbB ReceptorsExtracellular Signal-Regulated MAP KinasesFemaleLigandsMembrane ProteinsOvarian FolliclePhosphorylationReceptors, Invertebrate PeptideReceptors, NotchSignal TransductionStem Cell NicheDrosophila ProteinsEgfr protein, DrosophilaEpidermal Growth FactorErbB ReceptorsExtracellular Signal-Regulated MAP KinasesLigandsMembrane ProteinsN protein, DrosophilaReceptors, Invertebrate PeptideReceptors, Notchspi protein, Drosophilawg protein, DrosophilaWnt1 ProteinDrosophilaEGFREpithelial stem cellNicheOvaryWnt

Identifiers

PMID30389852
PMCPMC6288384
OpenAlexW2899698612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.