ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
The Relationship between Age, Neural Differentiation, and Memory Performance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Trial
- Effects of age on memory-related category-selective connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Aging shifts hippocampal reactivation from selective reinstatement to category-level misbinding during episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cognitive network plasticity across divergent aging trajectories: an exploratory graph-theoretic study.GeroScience · 2026Article
- Encoding-related fMRI BOLD activity predicts subsequent memory for studied scenes, but not subsequent identification of perceptually similar lures.bioRxiv : the preprint server for biology · 2026Article
- Age-related differences in spatial memory occur alongside reduced visual fMRI BOLD but preserved viewpoint-specific scene representations.bioRxiv : the preprint server for biology · 2026Article
- Age-related differences in brain activity despite matched cognitive performance: A moderated-mediation analysis.Brain imaging and behavior · 2026Article
- When Alzheimer's pathology meets cardiometabolic risk: intrinsic subcortical-cortical connectivity signatures of retroactive interference in aging.Alzheimer's research & therapy · 2026Article
- Neural mechanisms underlying the effects of visual input on static balance in older adults with mild cognitive impairment.Frontiers in neuroscience · 2026Article
- Non-invasive brain stimulation on functional capacity in prefrail older adults: a protocol for a randomised clinical trial.Frontiers in aging neuroscience · 2026Article
- Effects of age on the strategic control of recollected content as reflected by modulation of neural correlates of scene retrieval.Neurobiology of aging · 2025Article
- Effects of cortical thickness, volume, and memory performance on age differences in neural reinstatement of scene information.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.Science advances · 2025Article
- Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults.Alzheimer's research & therapy · 2025Article
- Diminished State Space Theory of Human Aging.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Article
- Neural effects of memory training to reduce false memories in older adults: Univariate and multivariate analyses.Neurobiology of aging · 2025Article
- Canonical cortico-hippocampal dynamics underlie memory of navigational episodes and its early decline in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Aging and episodic memory specificity: Evidence challenging a domain-general pattern separation decline.PloS one · 2025Article
- Article
- Cross-sectional and Longitudinal Age-related Disintegration in Functional Connectivity: Reference Ability Neural Network Cohort.Journal of cognitive neuroscience · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
Abstract
Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-selective cortical regions. This finding has prompted the suggestion that dedifferentiation contributes to age-related cognitive decline. Consistent with this possibility, dedifferentiation has been reported to negatively correlate with fluid intelligence in older adults. Here, we examined whether dedifferentiation is associated with performance in another cognitive domain-episodic memory-that is also highly vulnerable to aging. Given the proposed role of dedifferentiation in age-related cognitive decline, we predicted there would be a stronger link between dedifferentiation and episodic memory performance in older than in younger adults. Young (18-30 years) and older (64-75 years) male and female humans underwent fMRI scanning while viewing images of objects and scenes before a subsequent recognition memory test. We computed a differentiation index in two regions of interest (ROIs): parahippocampal place area (PPA) and lateral occipital complex (LOC). This index quantified the selectivity of the BOLD response to preferred versus nonpreferred category of an ROI (scenes for PPA, objects for LOC). The differentiation index in the PPA, but not the LOC, was lower in older than in younger adults. Additionally, the PPA differentiation index predicted recognition memory performance for the studied items. This relationship was independent of and not moderated by age. The PPA differentiation index also predicted performance on a latent "fluency" factor derived from a neuropsychological test battery; this relationship was also age invariant. These findings suggest that two independent factors, one associated with age, and the other with cognitive performance, influence neural differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.