Evidence map›Paper›PMID 30389822›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2019

PET Imaging of PARP Expression Using

Thomas C Wilson, Mary-Ann Xavier, James Knight, Stefan Verhoog, Julia Baguña Torres, Michael Mosley, Samantha L Hopkins, Sheena Wallington, Phillip D Allen, Veerle Kersemans and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Imaging poly(ADP-ribose) polymerase-1 (PARP1)Acta pharmaceutica Sinica. B · 2025
    Article
  4. Review
  5. Article
  6. Development and evaluation of aEJNMMI radiopharmacy and chemistry · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Pharmacodynamic Activity of [JCO precision oncology · 2024
    Article
  13. [Journal of clinical medicine · 2024
    Review
  14. Review
  15. Article
  16. Article
  17. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  18. Targeted Alpha-Particle Therapy: A Review of Current Trials.International journal of molecular sciences · 2023
    Review
  19. Reactive Palladium-Ligand Complexes forPharmaceuticals (Basel, Switzerland) · 2023
    Review
  20. PET imaging of PARP expression usingEuropean journal of nuclear medicine and molecular imaging · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Thomas C WilsonDepartment of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Mary-Ann XavierCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
James KnightCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Stefan VerhoogDepartment of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Julia Baguña TorresCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Michael MosleyCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Samantha L HopkinsCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Sheena WallingtonCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Phillip D AllenCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Veerle KersemansCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Rebekka HuetingCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Sean SmartCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.
Véronique GouverneurDepartment of Chemistry, University of Oxford, Oxford, United Kingdom; and.
Bart CornelissenCRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom bart.cornelissen@oncology.ox.ac.uk veronique.gouverneur@oncology.ox.ac.uk.
University of Oxford · GBCRUK/MRC Oxford Institute for Radiation Oncology · GBScience Oxford · GB

Funding

Cancer Research UK 16466Cancer Research UK 23970Medical Research Council MR/R01695X/1
6 · The paper itself

Abstract

Poly(ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a radiolabeled inhibitor has been proposed for patient selection, outcome prediction, dose optimization, genotoxic therapy evaluation, and target engagement imaging of novel PARP-targeting agents.

Indexed as

Fluorine RadioisotopesGene Expression Regulation, EnzymologicPhthalazinesPiperazinesPositron-Emission TomographyAnimalsBoronic AcidsCell Line, TumorCell Transformation, NeoplasticCopperMiceMice, Inbred BALB CPoly(ADP-ribose) PolymerasesRadiochemistryTumor HypoxiaBoronic AcidsCopperFluorine-18Fluorine RadioisotopesolaparibPhthalazinesPiperazinesPoly(ADP-ribose) Polymerasescancermolecular imagingolaparibPARPPET

Identifiers

PMID30389822
PMCPMC6448459
OpenAlexW2898838695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.