Evidence map›Paper›PMID 30389807›Full record

ArticleGenetics2018

Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein.

Roberto Perales, Daniel Pagano, Gang Wan, Brandon D Fields, Arneet L Saltzman, Scott G Kennedy

Abstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  20. Small RNAs and chromatin in the multigenerational epigenetic landscape ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roberto PeralesDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.ORCID 0000-0002-3964-9734
Daniel PaganoDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Gang WanDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Brandon D FieldsDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
Arneet L SaltzmanDepartment of Cell and Systems Biology, University of Toronto, Ontario M5S 3G5, Canada.
Scott G KennedyDepartment of Genetics, Harvard Medical School, Boston, Massachusetts 02115 kennedy@genetics.med.harvard.edu.

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Small Regulatory RNA Functions In The NucleusR01GM088289 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KENNEDY, SCOTT G · 2009 to 2022
$4.4M
NIGMS NIH HHS R01 GM088289NIGMS NIH HHS T32 GM007133NIH HHS P40 OD010440
6 · The paper itself

Abstract

Transgenerational epigenetic inheritance (TEI) is the inheritance of epigenetic information for two or more generations. In most cases, TEI is limited to a small number of generations (two to three). The short-term nature of TEI could be set by innate biochemical limitations to TEI or by genetically encoded systems that actively limit TEI. In

Indexed as

RNA InterferenceAnimalsArgonaute ProteinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusChromatinEnhancer Elements, GeneticEpigenesis, GeneticGene SilencingInheritance PatternsNuclear ProteinsProtein KinasesRNA, Double-StrandedArgonaute ProteinsCaenorhabditis elegans ProteinsChromatinheri-1 protein, C elegansHRDE-1 protein, C elegansNuclear ProteinsProtein KinasesRNA, Double-StrandedchromatinRNAismall RNAstransgenerational epigenetic inheritance

Identifiers

PMID30389807
PMCPMC6283161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.