ArticleScience immunology2018
Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets.
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Article in Science immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection.Frontiers in immunology · 2019Trial
- Long-term depletion of KIR3DL01+ NK cells by adeno-associated viral-vectored antibody delivery alters chronic SIV infection.PLoS pathogens · 2026Article
- barbieQ: an R software package for analysing barcode count data from clonal tracking experiments.Bioinformatics (Oxford, England) · 2026Article
- Clonal dynamics, tolerance, and adverse events after CD45-ADC-conditioned autologous HSPC transplantation in macaques.Blood advances · 2026Article
- Application of a novel branched-DNA assay to quantify killer immunoglobulin-like receptor (KIR) mRNA expression identifies tissue compartmentalization in naïve and SIV-infected rhesus macaques.Journal of immunological methods · 2026Article
- Multiplexed iPSC platform for advanced NK cell immunotherapies.Cell reports. Medicine · 2025Review
- Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells.Molecular therapy. Methods & clinical development · 2025Article
- Pivotal role of exogenous pyruvate in human natural killer cell metabolism.Nature metabolism · 2025Article
- Long-term tracking of haematopoietic clonal dynamics and mutations in non-human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells.British journal of haematology · 2024Article
- Challenges and innovations in hematopoietic stem cell transplantation: exploring bone marrow niches and new model systems.BMB reports · 2024Review
- Cancer immunity by tissue-resident type 1 innate lymphoid cells and killer innate-like T cells.Immunological reviews · 2024Review
- Ongoing production of tissue-resident macrophages from hematopoietic stem cells in healthy adult macaques.Blood advances · 2024Article
- FcRγ- NK Cell Induction by Specific Cytomegalovirus and Expansion by Subclinical Viral Infections in Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies.BMC bioinformatics · 2023Article
- Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations.Molecular therapy oncolytics · 2023Article
- Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques.Molecular therapy. Methods & clinical development · 2023Article
- Characterization of natural killer cells in the blood and airways of cynomolgus macaques during Mycobacterium tuberculosis infection.Journal of medical primatology · 2023Article
- Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.Nature immunology · 2022Article
- Thanks for the NK cell memories.Nature immunology · 2022Article
- Article
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Authors and funding
19 authors at 10 institutions in 5 countries.
Chuanfeng WuDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5509-5754
Diego A EspinozaDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-9627-6508
Samson J KoelleDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Di YangDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0002-5608-6961
Lauren TruittDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Heinrich SchlumsDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Stockholm, Sweden.
Bernard A LafontViral Immunology Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.ORCID 0000-0003-2140-6205
Jan K Davidson-MoncadaDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Rong LuEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-5151-9246
Amitinder KaurTulane National Primate Research Center, Covington, LA, USA.
Quirin HammerDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Stockholm, Sweden.ORCID 0000-0003-2968-6061
Brian LiDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-7321-776X
Sandhya PanchDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
David A AllanDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Robert E DonahueDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Richard W ChildsDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA.
Chiara RomagnaniDeutsches Rheuma-Forschungszentrum-A Leibnitz Institute, Charite Medical University, Berlin, Germany.ORCID 0000-0002-5167-7463
Yenan T BrycesonDepartment of Medicine Huddinge, Karolinska Institutet, Huddinge, Stockholm, Sweden. dunbarc@nhlbi.nih.gov yenan.bryceson@ki.se.
Cynthia E DunbarDivision of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. dunbarc@nhlbi.nih.gov yenan.bryceson@ki.se.ORCID 0000-0002-7645-838X
National Heart Lung and Blood Institute · USKarolinska Institutet · SEBeth Israel Deaconess Hospital · USBroad Center · USGerman Rheumatism Research Centre · DEMacroGenics (United States) · USNational Institute of Allergy and Infectious Diseases · USTulane University · USUnion Hospital · CNUniversity of Washington · US
Funding
Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MAllogeneic Immunotherapy for cancer and nonmalignant hematological disordersZIAHL002345 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHILDS, RICHARD · 2009 to 2025
$53.3MRetroviral Mediated Gene Transfer Into Primate Hematopoietic CellsZICHL002338 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DONAHUE, ROBERT E · 2010 to 2018
$30.5MOptimization of gene transfer safety and efficacy focusing on the NHP modelZIAHL002339 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2009 to 2025
$26.8MRetroviral Mediated Gene Transfer Into Primate Hematopoietic CellsZIAHL002338 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI HONG, SO GUN · 2019 to 2025
$26.3MUnderstanding hematopoietic stem cell mobilization and engraftmentZIAHL006063 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 2010 to 2025
$23.5MVirus Induction Of Primary CD8 T Cell ResponsesZIAAI000814 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI BENNINK, JACK R · 2009 to 2020
$6.8MPRECLINICAL AND CLINICAL GENE TRANSFER TO HUMAN HEMATOPOIETIC STEM CELLSZ01HL002339 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI DUNBAR, CYNTHIA E · 1992 to 2008
$6.2MINTERACTIONS BETWEEN CMV AND SIV IN RHESUS MACAQUESR01AI043890 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KAUR, AMITINDER · 1998 to 2007
$2.4MIntramural NIH HHS Z01 HL002339Intramural NIH HHS Z99 HL999999Intramural NIH HHS ZIA HL002339Intramural NIH HHS ZIA HL006063Intramural NIH HHS ZIC HL002338NIAID NIH HHS R01 AI043890NIH HHS P51 OD011104
Abstract
Natural killer (NK) cells recognize and eliminate infected and malignant cells. Their life histories are poorly understood, particularly in humans, due to lack of informative models and endogenous clonal markers. Here, we apply transplantation of barcoded rhesus macaque hematopoietic cells to interrogate the landscape of NK cell production, expansion, and life histories at a clonal level long term and after proliferative challenge. We identify oligoclonal populations of rhesus CD56
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AnimalsClone CellsKiller Cells, NaturalMacaca mulatta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.