Evidence map›Paper›PMID 30389789›Full record

ArticleThe Journal of biological chemistry2018

Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects.

Emily J Simon, Adam D Linstedt

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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  16. Genetic glycoengineering in mammalian cells.The Journal of biological chemistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emily J SimonFrom the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
Adam D LinstedtFrom the Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 linstedt@cmu.edu.ORCID 0000-0003-0754-1638
Carnegie Mellon University · US

Funding

Cell-Based Sensors and Drug-Like Moldulators Targeting ppGalNAc-TransferasesU01CA230677 · NCI · CARNEGIE-MELLON UNIVERSITY · PI LINSTEDT, ADAM D · 2018 to 2020
$1.0M
DRUG-LIKE MODULATORS TARGETING O-GLYCOSYLATION BY GalNAc TRANSFERASE-2/3R21DE026714 · NIDCR · CARNEGIE-MELLON UNIVERSITY · PI LINSTEDT, ADAM D · 2016 to 2017
$584k
NCI NIH HHS U01 CA230677NIDCR NIH HHS R21 DE026714
6 · The paper itself

Abstract

The surface glycoprotein (GP) of Ebola virus causes many of the virus's pathogenic effects, including a dramatic loss of endothelial cell adhesion associated with widespread hemorrhaging during infection. Although the GP-mediated deadhesion depends on its extracellular mucin-like domain, it is unknown whether any, or all, of this domain's densely clustered

Indexed as

Cell AdhesionBinding SitesEbolavirusGlycosylationHEK293 CellsHumansN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseProtein BindingSubstrate SpecificityViral Fusion ProteinsN-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseViral Fusion ProteinsacetylgalactosaminyltransferaseadhesiondeadhesionEbola virusglycoproteinglycosylationmucin-like domainpathogenesisppGalNAc-T1viral protein

Identifiers

PMID30389789
PMCPMC6314128
OpenAlexW2899109654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.