Evidence map›Paper›PMID 30389766›Full record

ArticleApplied and environmental microbiology2019

Gut Symbionts Lactobacillus reuteri R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor.

Mustafa Özçam, Restituto Tocmo, Jee-Hwan Oh, Amin Afrazi, Joshua D Mezrich, Stefan Roos, Jan Claesen, Jan-Peter van Pijkeren

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 52 citations in OpenAlex.

  1. Trial
  2. Review
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  4. Article
  5. Article
  6. The role of the AHR in host-pathogen interactions.Nature reviews. Immunology · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
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  15. Article
  16. Review
  17. The role of potential probiotic strainsFrontiers in microbiology · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mustafa ÖzçamDepartment of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Restituto TocmoDepartment of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jee-Hwan OhDepartment of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Amin AfraziDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joshua D MezrichDepartment of Surgery, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Stefan RoosDepartment of Molecular Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Jan ClaesenDepartment of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Jan-Peter van PijkerenDepartment of Food Science, University of Wisconsin-Madison, Madison, Wisconsin, USA vanpijkeren@wisc.edu.
University of Wisconsin–Madison · USCleveland Clinic Lerner College of Medicine · USSwedish University of Agricultural Sciences · SE

Funding

TRAINING IN NUTRITIONT32DK007665 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GUY E GROBLEWSKI, Chi- Liang Eric Yen · 1993 to 2026
$9.2M
NIDDK NIH HHS T32 DK007665
6 · The paper itself

Abstract

A mechanistic understanding of microbe-host interactions is critical to developing therapeutic strategies for targeted modulation of the host immune system. Different members of the gut symbiont species

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell Line, TumorGastrointestinal MicrobiomeLimosilactobacillus reuteriMicePolyketide SynthasesReceptors, Aryl HydrocarbonSymbiosisAhr protein, mouseBasic Helix-Loop-Helix ProteinsPolyketide SynthasesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorbiosynthetic gene clustergut symbiontLactobacillus reuteripigmentpolyketidesprobioticsecondary metabolism

Identifiers

PMID30389766
PMCPMC6498181
OpenAlexW2899299926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.