ArticleDiabetes2019
GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
9.5field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Comparing GLP-1 agonists versus other weight loss interventions on risk of atrial fibrillation recurrence after catheter ablation: a meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Pooled it
- Effects of Glucagon-Like Peptide 1 Receptor Agonists on Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Meta-analysis.Advances in therapy · 2024Pooled it
- The Value of Microbiome-targeted Therapy on Lipid Indices of Patients with Type 2 Diabetes Mellitus: An Umbrella Meta-analysis of Randomized Controlled Trials.Current diabetes reviews · 2024Pooled it
- Effect of the glucagon-like peptide-1 analogue liraglutide versus placebo treatment on circulating proglucagon-derived peptides that mediate improvements in body weight, insulin secretion and action: A randomized controlled trial.Diabetes, obesity & metabolism · 2021Trial
- The therapeutic approach to cardiovascular-kidney-metabolic syndrome.Nature reviews. Nephrology · 2026Review
- Computational discovery of fenugreek-paitan-turmeric (FPT) bioactive compounds targeting SGLT2 and DPP-4 for glucose homeostasis regulation.Journal of Taibah University Medical Sciences · 2026Article
- Incretin-Based Therapies: A Novel Pathway in Addiction Treatment.Journal of clinical medicine · 2026Review
- Diabetes Mellitus and Atrial Fibrillation: Mechanistic Insights and Therapeutic Impacts of Glucose-Lowering Drugs.Life (Basel, Switzerland) · 2025Review
- Glucagon-Like Peptide 1 (GLP-1) Action on Hypothalamic Feeding Circuits.Endocrinology · 2025Review
- Ketotic Hypoglycaemia Following Sleeve Gastrectomy.Clinical endocrinology · 2025Article
- Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Malignancy in Pancreatic Neuroendocrine Tumour (pNET) Cells: Novel Routes for Therapeutic Targeting.Molecules (Basel, Switzerland) · 2025Article
- Therapeutic Potential of GLP-1 Receptor Agonists in Heart Failure with Preserved Ejection Fraction (HFpEF) in Obese Patients.Current heart failure reports · 2025Review
- Active targeting of type 1 diabetes therapies to pancreatic beta cells using nanocarriers.Diabetologia · 2025Review
- Hyperglucagonemia and glucagon hypersecretion in early type 2 diabetes result from multifaceted dysregulation of pancreatic mouse α-cells.Pflugers Archiv : European journal of physiology · 2025Article
- Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review.Frontiers in clinical diabetes and healthcare · 2025Review
- A Comprehensive Review on the Pharmacokinetics and Drug-Drug Interactions of Approved GLP-1 Receptor Agonists and a Dual GLP-1/GIP Receptor Agonist.Drug design, development and therapy · 2025Review
- GLP-1 receptor agonists and gallbladder disease risk: insights into molecular mechanisms and clinical implications.Therapeutic advances in endocrinology and metabolism · 2025Review
- Review
- Glucagon-like peptide-1 receptor: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024 · on this mapReview
- GLP-1 receptor agonists and myocardial metabolism in atrial fibrillation.Journal of pharmaceutical analysis · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Yanqing ZhangSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Keshab R ParajuliSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Genevieve E FavaSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Rajesh GuptaSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Weiwei XuSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Lauren U NguyenSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Anadil F ZakariaSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.
Vivian A FonsecaSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.ORCID 0000-0002-3381-7151
Hongjun WangDepartment of Surgery, Medical University of South Carolina, Charleston, SC.ORCID 0000-0001-7421-1917
Franck Mauvais-JarvisSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA.ORCID 0000-0002-0874-0754
Kyle W SloopDiabetes and Complications, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN.ORCID 0000-0001-6748-9929
Hongju WuSection of Endocrinology, Department of Medicine, Tulane University Health Science Center, New Orleans, LA hwu3@tulane.edu.ORCID 0000-0003-0926-8655
Tulane University · USEli Lilly (United States) · USMedical University of South Carolina · US
Funding
Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1MTargeting the estrogen receptor-α to protect functional β-cell mass in womenR01DK074970 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Franck Mauvais-Jarvis · 2007 to 2026
$6.0MImproving Islet Transplantation Outcome With Akt1R01DK081463 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HONGJU · 2009 to 2013
$1.6MRepurposing estrogens to improve pancreatic islet transplantationR01DK107444 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI MAUVAIS-JARVIS, FRANCK · 2016 to 2019
$1.5MPax4-induced alpha-to-beta cell conversionR01DK107412 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI WU, HONGJU · 2016 to 2018
$1.0MThe role of the androgen receptor in insulin secretionI01BX003725 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI MAUVAIS-JARVIS, FRANCK · 2018 to 2022
–BLRD VA I01 BX003725NIDDK NIH HHS R01 DK074970NIDDK NIH HHS R01 DK081463NIDDK NIH HHS R01 DK107412NIDDK NIH HHS R01 DK107444NIGMS NIH HHS U54 GM104940
Abstract
Glucagon-like peptide 1 (GLP-1) is known to suppress glucagon secretion, but the mechanism by which GLP-1 exerts this effect is unclear. In this study, we demonstrated GLP-1 receptor (GLP-1R) expression in α-cells using both antibody-dependent and antibody-independent strategies. A novel α-cell-specific GLP-1R knockout (αGLP-1R
Indexed as
AnimalsFemaleFlow CytometryGlucagonGlucagon-Like Peptide-1 ReceptorGlucagon-Secreting CellsGlucoseGlucose Tolerance TestImmunohistochemistryMiceMice, KnockoutReverse Transcriptase Polymerase Chain ReactionGlucagonGlucagon-Like Peptide-1 ReceptorGlucose
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.