ArticleDiabetes2019
DNA Sequence Variation in
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Article in Diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.Nature genetics · 2022Pooled it
- Human Genetics of Adipose Dysfunction: Genomic Mechanisms and Therapeutic Opportunities in Cardiometabolic Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Prevalence and factors associated with metabolic syndrome and its components among overweight and obese reproductive-age women in Bac Giang, Vietnam.Scientific reports · 2025Article
- The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction: A Novel Framework to Explain Pathogenesis and Guide Treatment.Journal of the American College of Cardiology · 2025Review
- Activin Actions in Adipocytes.The Journal of clinical endocrinology and metabolism · 2025Review
- Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3.Nature communications · 2025Article
- Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling.Nature communications · 2025Article
- RNA-Seq transcriptome profiling of Nile rat livers reveals novel insights on the anti-diabetic mechanisms of Water-Soluble Palm Fruit Extract.Journal of applied genetics · 2024Article
- Article
- The Effects ofAnimals : an open access journal from MDPI · 2024Article
- Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7.The Biochemical journal · 2024Article
- Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling.medRxiv : the preprint server for health sciences · 2024Article
- Human ACVR1C missense variants that correlate with altered body fat distribution produce metabolic alterations of graded severity in knock-in mutant mice.Molecular metabolism · 2024Article
- Hepatic Activin E mediates liver-adipose inter-organ communication, suppressing adipose lipolysis in response to elevated serum fatty acids.Molecular metabolism · 2023Article
- Study on Potential Differentially Expressed Genes in Idiopathic Pulmonary Fibrosis by Bioinformatics and Next-Generation Sequencing Data Analysis.Biomedicines · 2023Article
- Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Targeting activin receptor-like kinase 7 ameliorates adiposity and associated metabolic disorders.JCI insight · 2023Article
- What Is the Exact Contribution ofGenes · 2022Article
- Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.Nature communications · 2022Article
- Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
25 authors at 11 institutions in 7 countries.
Connor A EmdinCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-2385-8259
Amit V KheraCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Krishna AragamCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Mary HaasCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Mark ChaffinProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Derek KlarinCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Pradeep NatarajanCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Alexander BickCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Seyedeh M ZekavatCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Akihiro NomuraCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Diego ArdissinoDivision of Cardiology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS.
Heribert SchunkertDeutsches Herzzentrum München, Technische Universität München, and Deutsches Zentrum für Herz-Kreislauf-Forschung, München, Germany.
Ruth McPhersonUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
Roberto ElosuaCardiovascular Epidemiology and Genetics, Hospital del Mar Medical Research Institute, Barcelona, Spain.
Matthew J BownDepartment of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, and NIHR Leicester Biomedical Research Centre, Leicester, U.K.
Usman BaberThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Jeanette ErdmannInstitute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Namrata GuptaProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
John DaneshCardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, U.K.
Danish SaleheenDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Stacey GabrielProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA.
Sekar KathiresanCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA skathiresan1@mgh.harvard.edu.ORCID 0000-0002-6201-5334
Broad Institute · USGerman Centre for Cardiovascular Research · DENIHR Leicester Biomedical Research Centre · GBCardiovascular Institute of the South · USCenter for Non-Communicable Diseases · PKCentre for Human Genetics · GBOspedale di Parma · ITUniversitat de Vic - Universitat Central de Catalunya · ESUniversity of Cambridge · GBUniversity of Mississippi Medical Center · USUniversity of Ottawa · CA
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI HALL, JOHN E · 2016 to 2025
$38.2MNorthwest Genomics CenterRC2HL102926 · NHLBI · UNIVERSITY OF WASHINGTON · PI GREEN, PHILIP P, NICKERSON, DEBORAH A · 2009 to 2009
$11.0MComprehensive Sequencing and Analysis of Variation in NHLBI CohortsRC2HL102925 · NHLBI · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, GABRIEL, STACEY · 2009 to 2009
$10.2MUsing genetic variation to study biology of blood lipids & coronary heart diseaseR01HL127564 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Pradeep Natarajan, Gina Marie Peloso · 2015 to 2026
$7.3MARRA - NHLBI Lung Cohorts Sequencing ProjectRC2HL102923 · NHLBI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, BARNES, KATHLEEN C · 2009 to 2009
$2.6MWHI Sequencing Project (WHISP)RC2HL102924 · NHLBI · OHIO STATE UNIVERSITY · PI CARLSON, CHRISTOPHER S, JACKSON, REBECCA D · 2009 to 2009
$2.1MPolygenic prediction of common, complex diseasesK08HG010155 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI KHERA, AMIT VIKRAM · 2018 to 2021
$1.1MHuman Exome Sequencing in Six Well-Phenotyped NHLBI CohortsRC2HL103010 · NHLBI · UNIVERSITY OF VIRGINIA · PI RICH, STEPHEN S. · 2009 to 2009
$817kBritish Heart Foundation CS/14/2/30841British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/10/33842British Heart Foundation RG/18/13/33946British Heart Foundation RG2000010Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U54 HG003067NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS R01 HL127564NHLBI NIH HHS RC2 HL102923NHLBI NIH HHS RC2 HL102924NHLBI NIH HHS RC2 HL102925NHLBI NIH HHS RC2 HL102926NHLBI NIH HHS RC2 HL103010NIGMS NIH HHS T32 GM007205NIGMS NIH HHS U54 GM115428
Abstract
A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that lower WHRadjBMI and protect against type 2 diabetes. We identified four variants in the gene
Indexed as
Activin Receptors, Type IAlgorithmsDiabetes Mellitus, Type 2ExomeGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansSequence Analysis, DNAActivin Receptors, Type IACVR1C protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.