ArticleEMBO reports2018
Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
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In one paragraph
Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Constitutively active glucagon receptor (GCGR) physiologically regulates body temperature in lizards.Science advances · 2026Article
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- Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.Cell death discovery · 2023Article
- The immune checkpoint B7-H3 (CD276) regulates adipocyte progenitor metabolism and obesity development.Science advances · 2022Article
- Whole-body endothermy: ancient, homologous and widespread among the ancestors of mammals, birds and crocodylians.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Establishment of Down's syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT.Human cell · 2022Article
- The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.Frontiers in endocrinology · 2022Article
- Transcriptome analysis revealed potential genes involved in thermogenesis in muscle tissue in cold-exposed lambs.Frontiers in genetics · 2022Article
- RCAN1.4 attenuates renal fibrosis through inhibiting calcineurin-mediated nuclear translocation of NFAT2.Cell death discovery · 2021Article
- Article
- Strain-specific differences in muscle CaThe Journal of experimental biology · 2021Article
- Differential Expression of Metabolism-Related Genes in Plateau Pika (Frontiers in genetics · 2021Article
- Combination effects of a fatty diet and exercise on the depressive state and cardioprotection in apolipoprotein E knockout mice with a change inThe Journal of international medical research · 2020Article
- Regulator of Calcineurin (RCAN): Beyond Down Syndrome Critical Region.Molecules and cells · 2020Review
- GSK3 inhibition with low dose lithium supplementation augments murine muscle fatigue resistance and specific force production.Physiological reports · 2020Article
- Uncoupling of sarcoendoplasmic reticulum calcium ATPase pump activity by sarcolipin as the basis for muscle non-shivering thermogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor Interacting Protein, Neurogranin, and Growth-Associated Protein 43.International journal of molecular sciences · 2020Review
- Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 4 countries.
David RotterDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Heshan PeirisDepartment of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.
D Bennett GrinsfelderDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alyce M MartinDepartment of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.
Jana BurchfieldDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Valentina ParraFaculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, Advanced Center for Chronic Diseases (ACCDiS) and Center for Exercise Metabolism and Cancer (CEMC), University of Chile, Santiago, Chile.
Christi HullDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cyndi R MoralesDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Claire F JessupDepartment of Anatomy and Histology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.
Dusan MatusicaDepartment of Anatomy and Histology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia.
Brian W ParksDepartment of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Aldons J LusisDivision of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Ngoc Uyen Nhi NguyenDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Misook OhDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Israel IyokeDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tanvi JakkampudiDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
D Randy McMillanDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hesham A SadekDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matthew J WattThe Department of Physiology and Monash Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Monash University, Clayton, Vic., Australia.
Rana K GuptaTouchstone Diabetes Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Melanie A PritchardDepartment of Biochemistry and Molecular Biology, Monash University, Melbourne, Vic., Australia.
Damien J KeatingDepartment of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia damien.keating@flinders.edu.au beverly.rothermel@utsouthwestern.edu.ORCID 0000-0002-0154-8305
Beverly A RothermelDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA damien.keating@flinders.edu.au beverly.rothermel@utsouthwestern.edu.ORCID 0000-0001-9037-6703
The University of Texas Southwestern Medical Center · USFlinders University · AUMonash University · AUAdvanced Center for Chronic Diseases · CLPohang University of Science and Technology · KRUniversity of California, Los Angeles · USUniversity of Wisconsin–Madison · US
Funding
Training CoreU54HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2015 to 2019
$7.8MEstablishment and Maintenance of Healthy Adipose Tissue in ObesityR01DK104789 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI GUPTA, RANA K · 2015 to 2024
$3.9MModulating Calcineurin Signaling Pathways in MuscleR01HL072016 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2003 to 2012
$3.7MCytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte survivalR01HL102478 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MAMMEN, PRADEEP P.A. · 2012 to 2016
$2.0MCalcineurin's role in circadian regulation of cardiac function and remodelingR01HL097768 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2009 to 2012
$1.6MNHLBI NIH HHS R01 HL072016NHLBI NIH HHS R01 HL097768NHLBI NIH HHS R01 HL102478NICHD NIH HHS U54 HD087351NIDDK NIH HHS R01 DK104789
Abstract
Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this approach, yet are not well understood. Here, we provide evidence that Regulator of Calcineurin 1 (
Indexed as
MetabolismThermogenesis3T3-L1 CellsAdipocytesAdipose TissueAdipose Tissue, BeigeAdipose Tissue, WhiteAdrenergic AgentsAnimalsCalcineurinCalcium-Binding ProteinsCell DifferentiationCold TemperatureFemaleInsulin ResistanceIntracellular Signaling Peptides and ProteinsAdrenergic AgentsCalcineurinCalcium-Binding ProteinsDSCR1 protein, mouseIntracellular Signaling Peptides and ProteinsMuscle ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProteolipidsRNA, MessengersarcolipinUncoupling Protein 1adaptive thermogenesisDown syndromeobesityRCAN1sarcolipin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.