Evidence map›Paper›PMID 30389723›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Etomidate Effects on Desensitization and Deactivation of

Yiwei Liao, Xiang Liu, Youssef Jounaidi, Stuart A Forman, Hua-Jun Feng

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. GABACell biology and toxicology · 2023
    Article
  2. The Influence of AA29504 on GABANeurochemical research · 2022
    Article
  3. GABAFrontiers in aging neuroscience · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Yiwei LiaoDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Y.L., X.L., Y.J., S.A.F., H.-J.F.); Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China (Y.L.); and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (X.L.).
Xiang LiuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Y.L., X.L., Y.J., S.A.F., H.-J.F.); Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China (Y.L.); and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (X.L.).
Youssef JounaidiDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Y.L., X.L., Y.J., S.A.F., H.-J.F.); Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China (Y.L.); and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (X.L.).
Stuart A FormanDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Y.L., X.L., Y.J., S.A.F., H.-J.F.); Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China (Y.L.); and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (X.L.) feng.huajun@mgh.harvard.edu saforman@mgh.harvard.edu.
Hua-Jun FengDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts (Y.L., X.L., Y.J., S.A.F., H.-J.F.); Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China (Y.L.); and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China (X.L.) feng.huajun@mgh.harvard.edu saforman@mgh.harvard.edu.
Sixth Affiliated Hospital of Sun Yat-sen University · CNHarvard University · USSun Yat-sen University · CN

Funding

Synthetic Chemistry CoreP01GM058448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KEITH W · 1999 to 2018
$33.6M
General Anesthetic Sites in GABA-A Receptor Subunit Interfacial PocketsR01GM089745 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI FORMAN, STUART A · 2010 to 2020
$3.8M
NIGMS NIH HHS P01 GM058448NIGMS NIH HHS R01 GM089745
6 · The paper itself

Abstract

Central

Indexed as

Dose-Response Relationship, DrugEtomidateGABA Agonistsgamma-Aminobutyric AcidGene ExpressionHEK293 CellsHumansHypnotics and SedativesReceptors, GABA-AEtomidateGABA AgonistsGABRA4 protein, humanGABRB3 protein, humanGABRD protein, humangamma-Aminobutyric AcidHypnotics and SedativesReceptors, GABA-A

Identifiers

PMID30389723
PMCPMC6304376
OpenAlexW2898777897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.