ArticleCancer research2019
Adipokines Deregulate Cellular Communication via Epigenetic Repression of
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- From Epigenetic Dysregulation to Therapeutic Reprogramming in Endometrial Cancer: A State-Response Framework for Treatment Resistance.International journal of molecular sciences · 2026Review
- Developing Nanoparticle-Based Therapeutics for Targeting the Microenvironment in Obesity-Induced Endometrial Cancer.Cellular and molecular bioengineering · 2025Article
- Endothelial senescence induced by PAI-1 promotes endometrial fibrosis.Cell death discovery · 2025Article
- Minimally Invasive and Emerging Diagnostic Approaches in Endometrial Cancer: Epigenetic Insights and the Promise of DNA Methylation.Diagnostics (Basel, Switzerland) · 2024Review
- PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms.Cell reports · 2024Article
- Adipose-derived stem cells promote glycolysis and peritoneal metastasis via TGF-β1/SMAD3/ANGPTL4 axis in colorectal cancer.Cellular and molecular life sciences : CMLS · 2024Article
- Epigenetic modifications in obesity-associated diseases.MedComm · 2024Review
- Update on Adipose Tissue and Cancer.Endocrine reviews · 2023Article
- miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer.Cancer science · 2023Article
- Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer.Journal of translational medicine · 2023Review
- The Multifaceted Role of Connexins in Tumor Microenvironment Initiation and Maintenance.Biology · 2023Review
- Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress.Cellular & molecular biology letters · 2022Article
- The impact of obesity and adipokines on breast and gynecologic malignancies.Annals of the New York Academy of Sciences · 2022Review
- Article
- PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer.Cell reports · 2020Article
- Body mass index-associated molecular characteristics involved in tumor immune and metabolic pathways.Cancer & metabolism · 2020Article
- Genome-wide DNA methylation analysis in obese women predicts an epigenetic signature for future endometrial cancer.Scientific reports · 2019Article
- The Role of Metabolic Syndrome in Endometrial Cancer: A Review.Frontiers in oncology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 6 institutions in 1 country.
Srikanth R PolusaniDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Yi-Wen HuangDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukie, Wisconsin.ORCID 0000-0003-1695-1153
Guangcun HuangDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0003-1695-1153
Chun-Wei ChenDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Chiou-Miin WangDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Li-Ling LinDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0001-9891-5900
Pawel OsmulskiDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Nicholas D LucioDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Lu LiuDepartment of Computer Science, North Dakota State University, Fargo, North Dakota.
Ya-Ting HsuDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Yufan ZhouDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Chun-Lin LinDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0001-9891-5900
Irene Aguilera-BarrantesDepartment of Pathology, Medical College of Wisconsin, Milwaukie, Wisconsin.
Philip T ValenteDepartment of Pathology, University of Texas Health San Antonio, San Antonio, Texas.
Edward R KostDepartment of Obstetrics and Gynecology, University of Texas Health San Antonio, San Antonio, Texas.
Chun-Liang ChenDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Eun Yong ShimDepartment of Radiation Oncology, University of Texas Health San Antonio, San Antonio, Texas.
Sang Eun LeeDepartment of Radiation Oncology, University of Texas Health San Antonio, San Antonio, Texas.
Jianhua RuanDepartment of Computer Science, University of Texas San Antonio, San Antonio, Texas.ORCID 0000-0002-5622-3137
Maria E GaczynskaDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Pearlly YanDepartment of Internal Medicine, Ohio State University, Columbus, Ohio.ORCID 0000-0003-1965-4920
Paul J GoodfellowDepartment of Obstetrics and Gynecology, Ohio State University, Columbus, Ohio.
David G MutchObstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri.
Victor X JinDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas.
Bruce J NicholsonDepartment of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas.ORCID 0000-0003-1649-7173
Tim H-M HuangDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas. kirma@uthscsa.edu huangt3@uthscsa.edu.ORCID 0000-0003-1695-1153
Nameer B KirmaDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas. kirma@uthscsa.edu huangt3@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USMedical College of Wisconsin · USThe Ohio State University · USNorth Dakota State University · USThe University of Texas at San Antonio · USWashington University in St. Louis · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MTISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5MSystems Analysis of Epigenomic Architecture in Cancer ProgressionU54CA217297 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, TIM H.-M. · 2017 to 2021
$9.3MOmics analysis of three-dimensional transcriptional regulationR01GM114142 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIN, VICTOR, LIN, SHILI · 2015 to 2024
$2.7MNovel epigenetic paradigm in endometrial cancer recurrenceR01CA172279 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HUANG, TIM H.-M. · 2014 to 2018
$1.5MUltra-Low and Single-Cell Transcriptome Analysis in Patient-Derived Rare CLL Precursor CellsR50CA211524 · NCI · OHIO STATE UNIVERSITY · PI YAN, PEARLLY · 2016 to 2020
$745kNCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA054174NCI NIH HHS R01 CA172279NCI NIH HHS R50 CA211524NCI NIH HHS U54 CA217297NIGMS NIH HHS R01 GM114142
Abstract
Emerging evidence indicates that adipose stromal cells (ASC) are recruited to enhance cancer development. In this study, we examined the role these adipocyte progenitors play relating to intercellular communication in obesity-associated endometrial cancer. This is particularly relevant given that gap junctions have been implicated in tumor suppression. Examining the effects of ASCs on the transcriptome of endometrial epithelial cells (EEC) in an
Indexed as
Cell CommunicationEpigenetic RepressionAdipokinesAdipose TissueAnimalsCell MovementCells, CulturedConnexin 43Diet, High-FatEndometrial NeoplasmsEpithelial CellsFemaleGap JunctionsHumansMiceMice, KnockoutAdipokinesConnexin 43GJA1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.