Evidence map›Paper›PMID 30389668›Full record

ArticleThe EMBO journal2019

The kinetochore module Okp1

Ekaterina A Anedchenko, Anke Samel-Pommerencke, Tra My Tran Nguyen, Sara Shahnejat-Bushehri, Juliane Pöpsel, Daniel Lauster, Andreas Herrmann, Juri Rappsilber, Alessandro Cuomo, Tiziana Bonaldi and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 45 citations in OpenAlex.

  1. Structure and function of the outer kinetochore.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Histone modification inComputational and structural biotechnology journal · 2023
    Review
  12. Review
  13. Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution.Frontiers in cell and developmental biology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Ekaterina A AnedchenkoDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Anke Samel-PommerenckeDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Tra My Tran NguyenDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Sara Shahnejat-BushehriDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Juliane PöpselDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Daniel LausterDepartment of Experimental Biophysics, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Andreas HerrmannDepartment of Experimental Biophysics, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Juri RappsilberWellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-5999-1310
Alessandro CuomoDepartment of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Tiziana BonaldiDepartment of Experimental Oncology, European Institute of Oncology, Milan, Italy.ORCID 0000-0003-3556-1265
Ann E Ehrenhofer-MurrayDepartment of Molecular Cell Biology, Institut für Biologie, Humboldt-Universität zu Berlin, Berlin, Germany ann.ehrenhofer-murray@hu-berlin.de.ORCID 0000-0001-8709-1942
Humboldt-Universität zu Berlin · DEEuropean Institute of Oncology · ITWellcome Centre for Cell Biology · GB

Funding

Wellcome Trust 103139Wellcome Trust 103139/Z/13/ZWellcome Trust 203149
6 · The paper itself

Abstract

Kinetochores are supramolecular assemblies that link centromeres to microtubules for sister chromatid segregation in mitosis. For this, the inner kinetochore CCAN/Ctf19 complex binds to centromeric chromatin containing the histone variant CENP-A, but whether the interaction of kinetochore components to centromeric nucleosomes is regulated by posttranslational modifications is unknown. Here, we investigated how methylation of arginine 37 (R37Me) and acetylation of lysine 49 (K49Ac) on the CENP-A homolog Cse4 from

Indexed as

Amino Acid SequenceAmino Acid SubstitutionCell Cycle ProteinsCentromereCentromere Protein AChromosomal Proteins, Non-HistoneDNA-Binding ProteinsKinetochoresMicrotubule-Associated ProteinsMutation, MissenseOrganisms, Genetically ModifiedProtein DomainsProtein Processing, Post-TranslationalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAme1 protein, S cerevisiaeCell Cycle ProteinsCentromere Protein AChromosomal Proteins, Non-HistoneCSE4 protein, S cerevisiaeDNA-Binding ProteinsMicrotubule-Associated ProteinsOkp1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsAme1centromereGcn5Okp1posttranslational modification

Identifiers

PMID30389668
PMCPMC6315295
OpenAlexW2899433105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.