ArticleThe EMBO journal2018
Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH.
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Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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46citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort.International journal of epidemiology · 2021Pooled it
- Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases.Signal transduction and targeted therapy · 2026Review
- Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.The EMBO journal · 2026Article
- ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion.The Journal of clinical investigation · 2026Article
- Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.Nature communications · 2026Article
- The role of ER-associated degradation and ER-phagy in health and disease.Signal transduction and targeted therapy · 2026Review
- Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling.Nature communications · 2025Article
- SEL1L regulates ER homeostasis in Sertoli cells but is dispensable for their function.Molecular biology of the cell · 2025Article
- Structural insights into the human HRD1 ubiquitin ligase complex.Nature communications · 2025Article
- SEL1L-HRD1-mediated ERAD in mammals.Nature cell biology · 2025Review
- Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.Trends in cell biology · 2025Review
- ER-associated degradation adapter Sel1L is required for CD8Cell reports · 2024Article
- Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.Nature communications · 2024Article
- Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.The Journal of clinical investigation · 2024Article
- SEL1L-HRD1 ER-associated degradation regulates leptin receptor maturation and signaling in POMC neurons in diet-induced obesity.Research square · 2024Article
- Endoplasmic reticulum stress and quality control in relation to cisplatin resistance in tumor cells.Frontiers in pharmacology · 2024Review
- Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism.JCI insight · 2023Article
- Identification of EGF Receptor and Thrombospondin-1 as Endogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells.International journal of molecular sciences · 2023Article
- The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes.Nature communications · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Asmita BhattacharyaDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-5669-8036
Shengyi SunDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Heting WangDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Ming LiuDivision of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Qiaoming LongCam-Su Mouse Genomic Resource Center, Soochow University, Suzhou, Jiangsu, China qmlong@suda.edu.cn lingq@med.umich.edu.ORCID 0000-0001-8243-589X
Lei YinDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sander KerstenNutrition Metabolism and Genomics Group, Wageningen University, Wageningen, The Netherlands.
Kezhong ZhangDepartment of Biochemistry, Microbiology, and Immunology, Center for Molecular Medicine and Genetics Wayne State University School of Medicine, Detroit, MI, USA.ORCID 0000-0002-6062-235X
Ling QiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA qmlong@suda.edu.cn lingq@med.umich.edu.ORCID 0000-0001-8229-0184
University of Michigan · USCornell University · USSoochow University · CNThe University of Texas Southwestern Medical Center · USTianjin Medical University General Hospital · CNWayne State University · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MSecretory Pathway Protein Degradation Maintains Insulin Biogenesis + SecretionR01DK111174 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, QI, LING · 2016 to 2024
$5.5MRegulation of Hepatic Steatosis by an ER Stress-Inducible Transcription Factor CRR01DK090313 · NIDDK · WAYNE STATE UNIVERSITY · PI Kezhong Zhang · 2011 to 2026
$5.0MNovel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MSignificance and mechanisms of hepatic ChREBPα induction via post-translational modifications in diet-induced NASHR01DK099593 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YIN, LEI · 2014 to 2025
$4.5MDefining the Central Role of ER-Associated Degradation (ERAD) in Neuroendocrine CellsR01DK120047 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2018 to 2021
$1.6MThe Role of Sel1L and ER Quality Control in AdipocytesR01DK105393 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2015 to 2018
$1.4MREGULATION OF IRE1A SIGNALING BY THE SEL1L-HRD1 ERAD COMPLEXR01GM113188 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI QI, LING · 2015 to 2018
$1.2MHoward Hughes Medical InstituteNIAMS NIH HHS P30 AR069620NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK090313NIDDK NIH HHS R01 DK099593NIDDK NIH HHS R01 DK105393NIDDK NIH HHS R01 DK111174NIDDK NIH HHS R01 DK120047NIDDK NIH HHS R01 DK120330NIGMS NIH HHS R01 GM113188
Abstract
Fibroblast growth factor 21 (Fgf21) is a liver-derived, fasting-induced hormone with broad effects on growth, nutrient metabolism, and insulin sensitivity. Here, we report the discovery of a novel mechanism regulating
Indexed as
Endoplasmic Reticulum-Associated DegradationEnergy MetabolismAnimalsCyclic AMP Response Element-Binding ProteinFibroblast Growth FactorsIntracellular Signaling Peptides and ProteinsLiverMiceMice, Mutant StrainsPPAR alphaProteinsTranscription, GeneticUbiquitinationUbiquitin-Protein LigasesCreb3l3 protein, mouseCyclic AMP Response Element-Binding Proteinfibroblast growth factor 21Fibroblast Growth FactorsIntracellular Signaling Peptides and ProteinsPPAR alphaPpara protein, mouseProteinsSel1h protein, mouseSyvn1 protein, mouseUbiquitin-Protein LigasesER quality controlFGF21gene transcriptionmetabolismSel1L‐Hrd1 ERAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.