Evidence map›Paper›PMID 30389451›Full record

SynthesisThe Lancet. Global health2019

Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis.

Saifon Chawanpaiboon, Joshua P Vogel, Ann-Beth Moller, Pisake Lumbiganon, Max Petzold, Daniel Hogan, Sihem Landoulsi, Nampet Jampathong, Kiattisak Kongwattanakul, Malinee Laopaiboon and 8 more

4 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Global health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 1,461 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,461citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05430100 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effect of usıng Breast mılk pacıfıer, Sucrose pacıfıer and pacıfıer ın reducıng the paın That Occurs durıng orogastrıc Tube ınsertıon ın Preterm Newborns

TypeinterventionalSponsorSaglik Bilimleri Universitesi Gulhane Tip FakultesiRan2022 to 2023Enrolled73ConditionsPreterm, Pain, Nursing CariesArmsThe effect of usıng breast mılk pacıfıer ın reducıng the paın that occurs durıng orogastrıc tube ınsertıon ın preterm newborns, The effect of usıng sucrose pacıfıer ın reducıng the paın that occurs durıng orogastrıc tube ınsertıon ın preterm newborns, The effect of usıng pacıfıer ın reducıng the paın that occurs durıng orogastrıc tube ınsertıon ın preterm newborns
NCT05508308 nacompletednot on this mapstarted 2022, after this paper: background citation

Automated Oxygen Control for Preterm Infants On Continuous Positive Airway Pressure (CPAP): Phase 1/2 Trial In Southwest Nigeria

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2022 to 2023Enrolled49ConditionsNeonatal Respiratory Distress Related Conditions, Neonatal Respiratory Failure, Prematurity, Oxygen ToxicityArmsOxyMate, Manual oxygen control
NCT06281262 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia

TypeobservationalSponsorGeneral University Hospital, PragueRan2023 to 2025Enrolled100ConditionsPreterm Birth, PreeclampsiaArmsPeripheral blood collection, Swab sample collection
NCT07695467 completednot on this mapstarted 2021, after this paper: background citation

Analysis of Hippo-YAP Pathway Genes and Proteins and Related miRNA-195, miRNA-181c, miRNA-200a, and miRNA-375 Expression in Maternal Blood, Placental Tissue, and Myometrial Tissue From Women With Term and Preterm Cesarean Delivery

TypeobservationalSponsorCumhuriyet UniversityRan2021 to 2024Enrolled44ConditionsPreterm Birth, Pregnancy, Preterm LaborArmsLaboratory Biomarker Analysis
3 · Its place in the literature

Who cites it

1,461 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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1,401 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Saifon ChawanpaiboonMaternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Joshua P VogelUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland. Electronic address: vogeljo@who.int.
Ann-Beth MollerUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland.
Pisake LumbiganonDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Max PetzoldHealth Metrics Unit, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Daniel HoganDepartment of Information, Evidence and Research, WHO, Geneva, Switzerland.
Sihem LandoulsiUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland.
Nampet JampathongDepartment of Epidemiology and Biostatistics, Khon Kaen University, Khon Kaen, Thailand.
Kiattisak KongwattanakulDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Malinee LaopaiboonDepartment of Epidemiology and Biostatistics, Khon Kaen University, Khon Kaen, Thailand.
Cameron LewisSir Charles Gairdner Hospital, Nedlands, WA, Australia.
Siwanon RattanakanokchaiDepartment of Epidemiology and Biostatistics, Khon Kaen University, Khon Kaen, Thailand.
Ditza N TengJoondalup Health Campus, Joondalup, WA, Australia.
Jadsada ThinkhamropDepartment of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Kanokwaroon WatananirunMaternal Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jun ZhangMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei ZhouMinistry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
A Metin GülmezogluUNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, WHO, Geneva, Switzerland.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundPreterm birth is the leading cause of death in children younger than 5 years worldwide. Although preterm survival rates have increased in high-income countries, preterm newborns still die because of a lack of adequate newborn care in many low-income and middle-income countries. We estimated global, regional, and national rates of preterm birth in 2014, with trends over time for some selected countries.

methodsWe systematically searched for data on preterm birth for 194 WHO Member States from 1990 to 2014 in databases of national civil registration and vital statistics (CRVS). We also searched for population-representative surveys and research studies for countries with no or limited CRVS data. For 38 countries with high-quality data for preterm births in 2014, data are reported directly. For countries with at least three data points between 1990 and 2014, we used a linear mixed regression model to estimate preterm birth rates. We also calculated regional and global estimates of preterm birth for 2014.

findingsWe identified 1241 data points across 107 countries. The estimated global preterm birth rate for 2014 was 10·6% (uncertainty interval 9·0-12·0), equating to an estimated 14·84 million (12·65 million-16·73 million) live preterm births in 2014. 12· 0 million (81·1%) of these preterm births occurred in Asia and sub-Saharan Africa. Regional preterm birth rates for 2014 ranged from 13·4% (6·3-30·9) in North Africa to 8·7% (6·3-13·3) in Europe. India, China, Nigeria, Bangladesh, and Indonesia accounted for 57·9 million (41×4%) of 139·9 million livebirths and 6·6 million (44×6%) of preterm births globally in 2014. Of the 38 countries with high-quality data, preterm birth rates have increased since 2000 in 26 countries and decreased in 12 countries. Globally, we estimated that the preterm birth rate was 9×8% (8×3-10×9) in 2000, and 10×6% (9×0-12×0) in 2014.

interpretationPreterm birth remains a crucial issue in child mortality and improving quality of maternal and newborn care. To better understand the epidemiology of preterm birth, the quality and volume of data needs to be improved, including standardisation of definitions, measurement, and reporting.

fundingWHO and the March of Dimes.

Indexed as

FemaleGlobal HealthHumansLinear ModelsPregnancyPremature Birth

Identifiers

PMID30389451
PMCPMC6293055

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.