ArticleJournal of Ayurveda and integrative medicine
Antimicrobial effect of herbal extract of Acacia arabica with triphala on the biofilm forming cariogenic microorganisms.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Impact of Acacia arabica Addition on Optical, Mechanical, and Fungicidal Properties of Polymethyl Methacrylate Denture Base Material.European journal of dentistry · 2026Article
- Evaluation of the Antifungal Efficacy of Natural Gum Acacia and Aloe Vera against Candida albicans on Conventional and Digital Denture Base Materials: An In Vitro Study.European journal of dentistry · 2026Article
- Effect of nano liposomal herbal extracts against biofilm formation and adherence of streptococcus mutans.Scientific reports · 2025Article
- Comparative Assessment of Efficacy of Cranberry Extract Mouthwash and Fluoride Mouthwash onInternational journal of clinical pediatric dentistry · 2025Article
- Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review.Heliyon · 2024Review
- Phytochemical profile and antimicrobial activity ofHeliyon · 2024Article
- Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention.Current issues in molecular biology · 2024Review
- Article
- In Silico and In Vitro Investigation of Phytochemicals Against Shrimp AHPND Syndrome Causing PirA/B Toxins of Vibrio parahaemolyticus.Applied biochemistry and biotechnology · 2023Article
- Exploring the Potential of a Herbal Nanoemulsion as an Antimicrobial Mouthwash.Applied biochemistry and biotechnology · 2023Article
- Ayurvedic Drug Triphala in Combination with Providone Iodine Mitigates Radiation-Induced Mucositis in Head and Neck Cancer Patients without Affecting the Tumor Response.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Exploring the biomedical potential of a novel modified glass ionomer cement against the pandrug-resistant oral pathogenJournal of oral microbiology · 2023Article
- Exploring the Potential of Natural Product-Based Nanomedicine for Maintaining Oral Health.Molecules (Basel, Switzerland) · 2022Review
- Anti-adherence and anti-bacterial activities ofDental research journal · 2022Article
- Management ofJournal of clinical medicine · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDental caries is a biofilm-related infectious disease with a multifactorial etiology, over five billion inhabitants have affected worldwide due to this disease.
objectiveAntimicrobial efficacy of a mixed herbal powder extract (MHPE) against cariogenic microorganisms was investigated. MATERIALS AND
methodsMIC, MBC, kinetics of killing, biofilm disruption and anticaries effect of MHPE were determined. For biofilm disruption, biofilms of Streptococcus mutans, Lactobacillus casei, Actinomyces viscosus and Candida albicans were treated with MHPE for 30 min and attached cells were quantified after staining. For live/dead staining biofilm assay, S. mutans biofilm treated with MHPE for 1min, 5min and 1 h was examined with confocal laser scanning system after live/dead staining. Efficacy was experimented by structural quality using Scanning Electron Microscope (SEM). Anticaries effect was determined by formation of caries-like lesion in continuous flow biofilm model.
resultsMHPE exhibited inhibition zones ranging from 12.5 to 24.0 mm. The highest inhibition zone was recorded at concentration of 50 μg/ml. MIC for S. mutans was between 12.23 and 36.7 μg/ml, while the MBC values ranged from 36.7 to 110.65 μg/ml. Inhibitory concentration of MHPE was three fold higher than CHLX. Significant reduction of cell count (49-95%) was observed with increasing time and higher concentration. Percentage biofilm reduction compare with negative control was 96.9% (A. viscosus), 94% (C. albicans), 99.8% (L. casei) and 91.7% (S. mutans). For MHPE-treated biofilm, live/dead staining demonstrated significant (p < 0.05) higher in deceased red fluorescence areas in all kinetics points from 53.6% (1min) to 85% (1h). SEM confirmed the damage in the outer layers of S. mutans. MHPE has components with effective antibacterial activity against caries-inducing microorganisms.
conclusionThe anti-adherence and anti-biofilm effect as well as the faster killing activity suggests that MHPE formula has effective antibacterial activity and could be a useful source of anti-cariogenic agents in near future.
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