Evidence map›Paper›PMID 30388818›Full record

ArticlePharmaceuticals (Basel, Switzerland)2018

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-

Isadora T S Bastos, Pedro de Sena M Pinheiro, Fanny N Costa, Miguel D Rocha, Carlos Mauricio R Sant'Anna, Delson Braz, Everton T Souza, Marco A Martins, Eliezer J Barreiro, Fabio F Ferreira and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Discovery ofACS bio & med chem Au · 2026
    Article
  2. Article
  3. Article
  4. Current pharmaceutical design · 2024
    Review
  5. The Magic Methyl and Its Tricks in Drug Discovery and Development.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Isadora T S BastosLabFisMed, State University of Rio de Janeiro, Physics Institute, Rio de Janeiro 20550-900, RJ, Brazil. isadoratairinne@gmail.com.
Pedro de Sena M PinheiroLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, RJ, Brazil. pedro_senamp@hotmail.com.ORCID 0000-0003-4148-4243
Fanny N CostaCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil. fannycosta@yahoo.com.br.ORCID 0000-0001-9368-5640
Miguel D RochaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, RJ, Brazil. miguelquimic@gmail.com.
Carlos Mauricio R Sant'AnnaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, RJ, Brazil. santanna@ufrrj.br.
Delson BrazLaboratory of Nuclear Instrumentation/COPPE, Federal University of Rio de Janeiro, Rio de Janeiro 21949-900, RJ, Brazil. delson@nuclear.ufrj.br.
Everton T SouzaPrograma de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. evertontenoriosouza@gmail.com.
Marco A MartinsPrograma de Pós-Graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil. mamartins56@me.com.
Eliezer J BarreiroLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, RJ, Brazil. ejbarreiro@ccsdecania.ufrj.br.
Fabio F FerreiraCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, SP, Brazil. ffurlanf@gmail.com.ORCID 0000-0003-1516-1221
Regina C BarrosoLabFisMed, State University of Rio de Janeiro, Physics Institute, Rio de Janeiro 20550-900, RJ, Brazil. cely_barroso@hotmail.com.ORCID 0000-0001-6348-694X
Carlos A M FragaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, P.O. Box 68023, Rio de Janeiro 21941-902, RJ, Brazil. cmfraga@ccsdecania.ufrj.br.ORCID 0000-0001-6733-7079
Universidade Federal do Rio de Janeiro · BRUniversidade do Estado do Rio de Janeiro · BRUniversidade Federal do ABC · BR

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Conselho Nacional de Desenvolvimento Científico e Tecnológico 402.289/2013-7, 304.667/2015-5, 432.001/2016-6 and 305.991/2017-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.918/2015 and E-26/010.001273/2016Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos 465.249/2014
6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a chronic cardiovascular disease that displays inflammatory components, which contributes to the difficulty of adequate treatment with the available therapeutic arsenal. In this context, the

Indexed as

adenosine A2A receptorchalcogen bondcrystal structure determinationN-acylhydrazonePDE4 inhibitorsigma-holeX-ray powder diffractometry

Identifiers

PMID30388818
PMCPMC6316713
OpenAlexW2899268254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.