Evidence map›Paper›PMID 30388807›Full record

ArticleInternational journal of molecular sciences2018

Plasma Derived Exosomal Biomarkers of Exposure to Ionizing Radiation in Nonhuman Primates.

Amrita K Cheema, Charles P Hinzman, Khyati Y Mehta, Briana K Hanlon, Melissa Garcia, Oluseyi O Fatanmi, Vijay K Singh

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

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  13. The emerging role of exosomes in radiotherapy.Cell communication and signaling : CCS · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Amrita K CheemaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. akc27@georgetown.edu.
Charles P HinzmanDepartment of Biochemistry, Molecular and Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USA. cph51@georgetown.edu.ORCID 0000-0002-4669-4357
Khyati Y MehtaDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. kym8@georgetown.edu.
Briana K HanlonDepartment of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. brianakh17@gmail.com.
Melissa GarciaDepartment of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. melissa.garcia.ctr@usuhs.edu.
Oluseyi O FatanmiDepartment of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. oluseyi.fatanmi@usuhs.edu.
Vijay K SinghDepartment of Pharmacology and Molecular Therapeutics, F. Edward Hébert School of Medicine, USUHS, Bethesda, MD 20814, USA. vijay.singh@usuhs.edu.ORCID 0000-0002-6631-3849
Uniformed Services University of the Health Sciences · USGeorgetown University · US

Funding

Congressionally Directed Medical Research Programs W81XWH-15-C-0117Defense Threat Reduction Agency CBM.RAD.01.10.AR.005
6 · The paper itself

Abstract

Exposure to ionizing radiation induces a cascade of molecular events that ultimately impact endogenous metabolism. Qualitative and quantitative characterization of metabolomic profiles is a pragmatic approach to studying the risks of radiation exposure since it provides a phenotypic readout. Studies were conducted in irradiated nonhuman primates (NHP) to investigate metabolic changes in plasma and plasma-derived exosomes. Specifically, rhesus macaques (

Indexed as

Radiation, IonizingAnimalsBiomarkersDiscriminant AnalysisExosomesFemaleLeast-Squares AnalysisLipid MetabolismMacaca mulattaMaleMetabolomicsBiomarkersbiomarkerexosomesgamma-radiationlipidomesmetabolitesnonhuman primatesplasma

Identifiers

PMID30388807
PMCPMC6274965
OpenAlexW2899215879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.