Evidence map›Paper›PMID 30388752›Full record

ArticleInsects2018

Fatty Acid and Related Potassium Kv2 Channel Blockers: Toxicity and Physiological Actions on Mosquitoes.

Fabien Démares, Quentin Coquerel, Gary Richoux, Kenneth Linthicum, Jeffrey Bloomquist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insects, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fabien DémaresNeurotoxicology Laboratory, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA. fabien.demares@ufl.edu.ORCID 0000-0002-2638-4247
Quentin CoquerelNeurotoxicology Laboratory, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA. quentin.coquerel@ufl.edu.
Gary RichouxNeurotoxicology Laboratory, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA. grichoux@ufl.edu.
Kenneth LinthicumUSDA, ARS, Center for Medical, Agricultural and Veterinary Entomology, Gainesville, FL 32608, USA. Kenneth.Linthicum@ars.usda.gov.
Jeffrey BloomquistNeurotoxicology Laboratory, Department of Entomology and Nematology, Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA. jbquist@epi.ufl.edu.ORCID 0000-0002-9136-4998
University of Florida · USCenter for Medical, Agricultural and Veterinary Entomology · US

Funding

Deployed War Fighter and USDA Specific Cooperative Agreements 58-0208-0-068 and 58-0208-5-001
6 · The paper itself

Abstract

Potassium channels constitute a very diverse group involved in neural signaling, neuronal activity, membrane potential maintenance, and action potential generation. Here, we tested the mammalian potassium channel blockers TRAM-34 and 5-hydroxydecanoate (5-HDC), as well as certain fatty acids (FA) that might fit in the lumen of the pore and block channel activity by obstructing K⁺ ion passage. Kv channel blockers could be leads for a novel pesticide type. Insecticidal activity was assessed by topical application to

Indexed as

Anopheles gambiaefatty acidspatch-clamppotassium channeltoxicity

Identifiers

PMID30388752
PMCPMC6315728
OpenAlexW2898689082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.