Trial reportNutrients2018
Randomized, Double-Blind, Placebo-Controlled Parallel Clinical Trial Assessing the Effect of Fructooligosaccharides in Infants with Constipation.
Trial report in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Efficacy and safety of non-pharmacological treatments for paediatric functional constipation: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Pooled it
- Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Daily consumption of galactooligosaccharide gummies ameliorates constipation symptoms, gut dysbiosis, degree of depression and quality of life among sedentary university teaching staff: A double-blind randomized placebo control clinical trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Trial
- Effect of Polydextrose/Fructooligosaccharide Mixture on Constipation Symptoms in Children Aged 4 to 8 Years.Nutrients · 2021Trial
- Review
- Galacto-oligosaccharides alone and combined with lactoferrin impact the Kenyan infant gut microbiota and epithelial barrier integrity during iron supplementationMicrobiome research reports · 2025Article
- Fructooligosaccharides for Relieving Functional Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Foods (Basel, Switzerland) · 2024Review
- Exploring the Prebiotic Potentials of Hydrolyzed Pectins: Mechanisms of Action and Gut Microbiota Modulation.Nutrients · 2024Review
- Xylo-oligosaccharides improve functional constipation by targeted enrichment ofFood science & nutrition · 2024Article
- Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.Nutrients · 2024Review
- Dietary Fibers in Healthy Children and in Pediatric Gastrointestinal Disorders: A Practical Guide.Nutrients · 2023Review
- Functional constipation in children: What physicians should know.World journal of gastroenterology · 2023Review
- Article
- Article
- Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications.Nutrients · 2021Review
- Activation of butyrate-producing bacteria as well as bifidobacteria in the cat intestinal microbiota by the administration of 1-kestose, the smallest component of fructo-oligosaccharide.The Journal of veterinary medical science · 2020Article
- The Constipation-Relieving Property of d-Tagatose by Modulating the Composition of Gut Microbiota.International journal of molecular sciences · 2019Article
- Probiotics and Prebiotics in Pediatrics: What Is New?Nutrients · 2019Article
- Diet-Microbe-Host Interactions That Affect Gut Mucosal Integrity and Infection Resistance.Frontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Constipation often begins in the first year of life. The aim of this study was to assess the effect of fructooligosaccharides (FOS) in the treatment of infants with constipation. This randomized, double-blind, placebo-controlled clinical trial included infants with constipation who were randomly assigned to one of two parallel groups: FOS or placebo. Either the FOS supplement or the placebo was added to the infant formula. Thirty-six infants completed the 4-week intervention. Therapeutic success occurred in 83.3% of the FOS group infants and in 55.6% of the control group infants (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.