Evidence map›Paper›PMID 30388744›Full record

ReviewPharmaceutics2018

Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation.

Stefania Ordanini, Francesco Cellesi

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stefania OrdaniniDipartimento di Chimica, Materiali ed Ingegneria Chimica "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy. stefania.ordanini@polimi.it.
Francesco CellesiDipartimento di Chimica, Materiali ed Ingegneria Chimica "G. Natta", Politecnico di Milano, Via Mancinelli 7, 20131 Milan, Italy. francesco.cellesi@polimi.it.ORCID 0000-0001-6106-9317

Funding

Fondazione Cariplo 2013-1047, Nanoparticelle - 2013Fondazione CEN - European Centre for Nanomedicine, Milan, Italy Start-up package grantRegione Lombardia POR FESR 2014 - 2020 - NeOn project (ID 239047)
6 · The paper itself

Abstract

Unimolecular polymeric micelles are a class of single-molecule amphiphilic core-shell polymeric architectures, where the hydrophobic core is well stabilized by the hydrophilic shell, avoiding intermolecular core-core interactions. Multi-arm copolymers with a dendritic core, as well as hyperbranched and comb-like polymers, can form unimolecular micelles easily. In this review, examples of polymers able to form detectable unimolecular micelles will be presented, summarizing the analytical techniques used to characterize the unimolecular micelles and discriminate them from other supramolecular aggregates, such as multi-micelle aggregates. Unimolecular micelles are suitable for the nanoencapsulation of guest molecules. Compared to traditional supramolecular micelles, unimolecular micelles do not disassemble under dilution and are stable to environmental modifications. Recent examples of their application as drug delivery systems, endowed with increased stability and transport properties, will be discussed.

Indexed as

complex polymeric architecturesdrug deliverynanoencapsulationunimolecular micellesunimolecular micelles characterization

Identifiers

PMID30388744
PMCPMC6321574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.