ArticleNutrients2018
Chitosan-Based Nanoparticles Containing Cherry Extract from
Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Biological Activity and Potential Health Benefits of EdiblePlants (Basel, Switzerland) · 2026Review
- Nanomaterials and exercise interventions: A synergistic approach for atherosclerosis therapy (Review).International journal of molecular medicine · 2026Review
- Review
- Thermo-Responsive Hydrogel Containing Microfluidic Chitosan Nanoparticles Loaded withInternational journal of molecular sciences · 2024Article
- Review
- Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications.International journal of molecular sciences · 2023Review
- Bergamot Essential Oil: A Method for Introducing It in Solid Dosage Forms.Foods (Basel, Switzerland) · 2022Article
- Comparing Metabolomic and Essential Oil Fingerprints ofAntioxidants (Basel, Switzerland) · 2022Article
- Enhanced Bioactivity of Pomegranate Peel Extract following Controlled Release from CaCOBioinorganic chemistry and applications · 2022Article
- Combination of Two Kinds of Medicated Microparticles Based on Hyaluronic Acid or Chitosan for a Wound Healing Spray Patch.Pharmaceutics · 2021Article
- Impact of Peels Extracts from an Italian Ancient Tomato Variety Grown under Drought Stress Conditions on Vascular Related Dysfunction.Molecules (Basel, Switzerland) · 2021Article
- Chitosan Nanoparticles as a Promising Nanomaterial for Encapsulation of Pomegranate (Nanomaterials (Basel, Switzerland) · 2021Article
- Thiolated Chitosans: A Multi-talented Class of Polymers for Various Applications.Biomacromolecules · 2021Review
- Current Advances in the Use of Nanophytomedicine Therapies for Human Cardiovascular Diseases.International journal of nanomedicine · 2021Review
- Nanoparticles Based on Quaternary Ammonium Chitosan-methyl-β-cyclodextrin Conjugate for the Neuropeptide Dalargin Delivery to the Central Nervous System: An In Vitro Study.Pharmaceutics · 2020Article
- Quaternary Ammonium Chitosans: The Importance of the Positive Fixed Charge of the Drug Delivery Systems.International journal of molecular sciences · 2020Review
- Therapeutic Potential of Polyphenols-Loaded Polymeric Nanoparticles in Cardiovascular System.Molecules (Basel, Switzerland) · 2020Review
- Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix.Pharmaceutics · 2020Review
- Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption.Foods (Basel, Switzerland) · 2020Review
- Antioxidant Effect of Cocoa By-Product and Cherry Polyphenol Extracts: A Comparative Study.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cherries are known for their nutraceutical properties, in particular for their antioxidant ability due to their polyphenol content, which causes a reduction of cardiovascular disease (CVD) risk factors. However, once ingested these molecules are degraded in the Gastrointestinal (GI) tract before reaching the blood, which is the action site. The object of the present work is to evaluate the ability of cherry extract (CE), encapsulated in nanoparticles (NPs) based on different chitosan (Ch) derivatives, to promote a protective effect of human umbilical vein endothelial cells (HUVECs) involved in vascular dysfunction against oxidative stress. CE-loaded NPs based on quaternary ammonium chitosan (NP1) and an S-protected thiolated derivative thereof (NP2) were prepared. The mean particle size (NP1 344.9 ± 17.8, NP2 339.9 ± 68.2 nm), the polydispersity index, the encapsulation efficiency (NP1 78.4 ± 4.5, NP2 79.8 ± 0.6%), and the zeta potential (NP1 14.8 ± 0.3, NP2 15.8 ± 0.5 mV) did not appear to be significantly different. Both NP types improved the CE apparent permeation parameters with respect to the control. Conversely, CE-loaded NP2 protected HUVECs from oxidative stress and reduced reactive oxygen species (ROS) production more than CE-loaded NP1 and free CE. In addition to promoting HUVEC resistance, NP2 could be a useful tool to overcome the problem of cherry seasonality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.