Evidence map›Paper›PMID 30388622›Full record

ArticleMolecular therapy. Nucleic acids2018

Cationic Oligospermine-Oligonucleotide Conjugates Provide Carrier-free Splice Switching in Monolayer Cells and Spheroids.

Marc Nothisen, Phanélie Perche-Létuvée, Jean-Paul Behr, Jean-Serge Remy, Mitsuharu Kotera

Abstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marc NothisenLaboratoire de Chimie Biofonctionnelle, Université de Strasbourg, CNRS, CAMB UMR 7199, LabEx MEDALIS, Faculté de Pharmacie, 67400 Illkirch, France.
Phanélie Perche-LétuvéeLaboratoire V-SAT, Université de Strasbourg, CNRS, CAMB UMR 7199, LabEx MEDALIS, Faculté de Pharmacie, 67400 Illkirch, France.
Jean-Paul BehrLaboratoire V-SAT, Université de Strasbourg, CNRS, CAMB UMR 7199, LabEx MEDALIS, Faculté de Pharmacie, 67400 Illkirch, France.
Jean-Serge RemyLaboratoire de Chimie Biofonctionnelle, Université de Strasbourg, CNRS, CAMB UMR 7199, LabEx MEDALIS, Faculté de Pharmacie, 67400 Illkirch, France. Electronic address: remy@unistra.fr.
Mitsuharu KoteraLaboratoire V-SAT, Université de Strasbourg, CNRS, CAMB UMR 7199, LabEx MEDALIS, Faculté de Pharmacie, 67400 Illkirch, France. Electronic address: m.kotera@unistra.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the evaluation of 18-mer 2'-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5' end to the oligospermine units (S

Indexed as

carrier-free oligonucleotide deliverycationic oligonucleotide-oligospermine conjugateexon skippingMCTSmulticellular tumor spheroidssplice switching oligonucleotidesSSO

Identifiers

PMID30388622
PMCPMC6205332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.