Evidence map›Paper›PMID 30388419›Full record

ArticleCell stem cell2018

The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.

Megan E McNerney, Michelle M Le Beau

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Cell and Gene Therapy for Anemia: Hematopoietic Stem Cells and Gene Editing.International journal of molecular sciences · 2021
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Megan E McNerneyDepartment of Pathology and the Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA; University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL 60637, US.
Michelle M Le BeauDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA; University of Chicago Medicine Comprehensive Cancer Center, Chicago, IL 60637, US. Electronic address: mlebeau@bsd.uchicago.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) describes clonal selection of a hematopoietic stem cell with a somatic mutation that confers increased fitness, influenced by a selective environment such as aging, inflammation, or therapeutic exposure. In this issue of Cell Stem Cell, Hsu et al. (2018) explore the role of cytotoxic therapy in disease-relevant CHIP.

Indexed as

Hematopoietic Stem CellsHematopoietic Stem Cell TransplantationHematopoiesisHumansInflammationMutationProtein Phosphatase 2CPPM1D protein, humanProtein Phosphatase 2C

Identifiers

PMID30388419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.