Evidence map›Paper›PMID 30388399›Full record

SynthesisAmerican journal of human genetics2018

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

Symen Ligthart, Ahmad Vaez, Urmo Võsa, Maria G Stathopoulou, Paul S de Vries, Bram P Prins, Peter J Van der Most, Toshiko Tanaka, Elnaz Naderi, Lynda M Rose and 278 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 245 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
245citing papers in PubMed, 19 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

245 citing papers in PubMed, 19 syntheses or guidelines pooled it, 446 citations in OpenAlex.

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185 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

288 authors at 20 institutions in 22 countries.

Symen LigthartDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands.
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
Urmo VõsaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Maria G StathopoulouUniversité de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France.
Paul S de VriesDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Bram P PrinsDepartment of Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
Peter J Van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Elnaz NaderiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Robert KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Maja BarbalicUniversity of Split School of Medicine, Split 21000, Croatia.
Honghuang LinDepartment of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
René PoolDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Gu ZhuQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Aurélien MacéDepartment of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland.
Carlo SidoreIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Massimo ManginoDepartment of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK; NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, UK.
Maria Sabater-LlealUnit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau, Barcelona 08025, Spain; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
John P KempUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Ali AbbasiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands; MRC Epidemiology Unit, University of Cambridge School of Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Tim KacprowskiDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald 17475, Germany; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany.
Niek VerweijUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands.
Albert V SmithIcelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Tao HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Carola MarziInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108-2212, USA.
Kurt K LohmanDepartment of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Yuri MilaneschiDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Christian MuellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; Institute of Medical Biometry and Statistics, University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck 23562, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany.
Mahmudul HuqDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Efthymia VlachopoulouTransplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Christopher OldmeadowHunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Joris DeelenMolecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.
Markus PerolaNational Institute for Health and Welfare, Helsinki 00271, Finland.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
LifeLines Cohort StudyDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Marzyeh AminiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
CHARGE Inflammation Working Group
Jari LahtiHelsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland.
Katharina E SchrautCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Myriam FornageHuman Genetics Center, School of Public Health and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Bhoom SuktitipatDepartment of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Wei-Min ChenCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Xiaohui LiInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Teresa NutileInstitute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.
Giovanni MalerbaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Jian'an LuanMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Tom BakInterdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Nicholas SchorkHuman Biology, J. Craig Venter Institute, La Jolla, CA 92037, USA; Quantitative Medicine, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.
Fabiola Del Greco MInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Elisabeth ThieringInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany.
Anubha MahajanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Evelin MihailovEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Joel ErikssonDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Ayse Bilge OzelDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
Maria NethanderBioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 90, Sweden.
Yu-Ching ChengDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
Wei AngMedical School, University of Western Australia, Perth, WA 6009, Australia.
Ilaria GandinAREA Science Park, Trieste 34149, Italy.
Loïc YengoCentre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Program in Complex Trait Genomics, Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, QLD 4072, Australia.
Laura PortasSupport OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy.
Charles KooperbergFred Hutchinson Cancer Research Center, Public Health Sciences Division, Mail Stop M3-A410, 1100 Fairview Ave. N., Seattle, WA, USA.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria; Institute of Medical Informatics, Statistics and Documentation, Medical University Graz, Graz 8036, Austria.
Kumar B RajanDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Claudia SchurmannCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wouter den HollanderDepartment of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Gentofte 2820, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Jing ZhaoCenter for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Harmen H M DraismaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands; Neuroscience Campus Amsterdam, Amsterdam 1081 HV, the Netherlands.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
Nicholas TimpsonMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Alexander TeumerDepartment SHIP-KEF, Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Hongyan HuangProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Simone WahlInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
YongMei LiuDepartment of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Jie HuangBoston VA Research Institute, Inc., Boston, MA 02130, USA.
Hae-Won UhMedical Statistics and Bioinformatics, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
Peter K JoshiCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Lisa R YanekGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Elisabetta TrabettiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Diego VozziInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Marie VerbanckCentre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France.
Ginevra BiinoInstitute of Molecular Genetics, Consiglio Nazionale delle Ricerche, Pavia 27100, Italy.
Yasaman SabaGottfried Schatz Research Center, Institute for Molecular Biology and Biochemistry, 8010 Graz, Austria.
Ingrid MeulenbeltDepartment of Medical Statistics and Bio-informatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Jeff R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Christie M BallantyneDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA.
Jouke Jan HottengaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Fernando RivadineiraDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Rico RueediDepartment of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Maristella SteriIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Karl-Heinz HerzigDepartment of Physiology, Institute of Biomedicine, University of Oulu, Medical Research Center Oulu and Oulu University Hospital, Oulu 90014, Finland; Biocenter Oulu, University of Oulu, Oulu 90220, Finland; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan 60-512, Poland.
David J StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Cristina MenniDepartment of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Mattias FrånbergCardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm 100 44, Sweden.
Beate St PourcainMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK; Donders Institute, Radboud University, Nijmegen 6525 XD, the Netherlands.
Stephan B FelixGerman Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Department for Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany.
Tune H PersDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark.
Stephan J L BakkerDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherber 85764, Germany.
Dhananjay VaidyaGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Graciela DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Johannes H SmitDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Vera GroßmannCenter for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany.
Juha SinisaloHeart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki 00029, Finland.
Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Stephen R WilliamsDepartment of Neurology, University of Virginia, Charlottesville, VA 22908, USA.
Elizabeth G HollidayHunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Matthijs MoedMolecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Katri RäikkönenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.
Jingzhong DingDepartment of Internal Medicine/Geriatrics, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Harry CampbellCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
Michele M SaleCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Yii-Der I ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Alan L JamesBusselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Daniela RuggieroInstitute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Nicole SoranzoSanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
Catharina A HartmanInterdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Erin N SmithDepartment of Pediatrics and Rady Children's Hospital, School of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Gerald S BerensonCenter for Cardiovascular Health, Tulane University, New Orleans, LA 70112, USA.
Christian FuchsbergerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Dena HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Carla M T TieslerInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Ludwig Maximilian University of Munich, Dr. von Hauner Children's Hospital, Munich 80337, Germany.
Vilmantas GiedraitisDepartment of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala 752 37, Sweden.
David LiewaldCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Krista FischerEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Dan MellströmDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Anders LarssonDepartment of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden.
Yunmei WangDepartment of Medicine, Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart & Vascular Institute, University Hospitals, Cleveland, OH 44106, USA.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Matthias LorentzonDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden; Geriatric Medicine, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.
John BeilbyPathWest Laboratory Medicine WA, Nedlands, WA 6009, Australia; School of Biomedical Sciences, University of Western Australia, Crawley, Perth, WA 6009, Australia.
Kathleen A RyanDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Craig E PennellMedical School, University of Western Australia, Perth, WA 6009, Australia.
Dragana VuckovicMedical Sciences, Surgical and Health Department, University of Trieste, Trieste 34137, Italy.
Beverly BalkauINSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Team 5 (EpReC, Renal, and Cardiovascular Epidemiology), Université de Versailles Saint-Quentin-en-Yvelines, Université Paris-Saclay, Villejuif 94807, France.
Maria Pina ConcasInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz 8036, Austria.
Carlos F Mendes de LeonDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Erwin P BottingerCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Lavinia PaternosterMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
A W MuskBusselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Gonneke WillemsenDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
David M EvansUniversity of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital, Tampere 33520, Finland; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Zoltán KutalikSwiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland.
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Ville KarhunenCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland.
Stephen B KritchevskyGerontology and Geriatric Medicine, Sticht Center on Aging and Rehabilitation, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
Naveed SattarBHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow G12 8TA, UK.
Genevieve LachanceDepartment of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Robert ClarkeClinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20520, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
John R AttiaHunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; John Hunter Hospital, New Lambton Heights, NWS 2305, Australia.
Diana van HeemstDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Eero KajantieChronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki 00014, Finland; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki 00290, Finland; Department of Obstetrics and Gynaecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu 90014, Finland.
Rossella SoriceInstitute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.
Giovanni GambaroDivision of Nephrology and Dialysis, Columbus-Gemelli University Hospital, Università Cattolica del Sacro Cuore, Roma 168, Italy.
Robert A ScottMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Andrew A HicksInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
Marie StandlInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany.
Cecilia M LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7FZ, UK; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer's Scotland Dementia Research Centre, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Magnus KarlssonDepartment of Clinical Sciences and Orthopaedic Surgery, Lund University, Malmo 20502, Sweden.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala 751 41, Sweden.
Jun Z LiDepartment of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
Trevor A MoriMedical School, University of Western Australia, Perth, WA 6009, Australia.
Eco J C N de GeusDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine, 4560 Clayton Ave., Suite 1000, St. Louis, MO 63110, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Juha AuvinenCenter for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland.
Brendan M BuckleyDepartment of Epidemiology and Public Health, University College Cork, Cork T12 K8AF, Ireland.
Anton J M de CraenDepartment of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
Melanie WaldenbergerInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Genetic Epidemiology, Institute of Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, Ludwig Maximilian University of Munich, Neuherberg 85764, Germany.
Thomas MeitingerInstitute of Human Genetics, Technische Universität München, Munich 85764, Germany; Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg 85764, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich 81377, Germany.
Rodney J ScottHunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Information-Based Medicine Stream, Hunter Medical Research Institute, New Lambton Heights, NSW 2305, Australia.
Mark McEvoyHunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
Marian BeekmanMolecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Cristina BombieriDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands.
John B WhitfieldQIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
David P StrachanPopulation Health Research Institute, St. George's, University of London, London SW17 0RE, UK.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands.
Peter VollenweiderDepartment of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne 1011, Switzerland.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
Marjo-Riitta JarvelinBiocenter Oulu, University of Oulu, Oulu 90220, Finland; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014 Oulun yliopisto, Finland; Unit of Primary Health Care, Oulu University Hospital, Oulu 90220, Finland; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Kingston Lane, Uxbridge, Middlesex UB8 3PH, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Durrer Center for Cardiogenetic Research, Amsterdam 3501 DG, the Netherlands; Interuniversity Cardiology Institute of the Netherlands, Utrecht 3511 EP, the Netherlands.
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Tanja ZellerDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; German Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany.
André G UitterlindenDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Matthias NauckGerman Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany; Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Harald GrallertInstitute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
Ingrid B BoreckiAnalytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim 68161, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Philipp S WildGerman Center for Cardiovascular Research, Partner Site RhineMain, 55131 Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University Mainz, Mainz 55131, Germany; Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.
Marja-Liisa LokkiTransplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland.
Michael BoyleJohn Hunter Hospital, New Lambton Heights, NWS 2305, Australia.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki 00271, Finland.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen 2300, Denmark; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Johan G ErikssonNational Institute for Health and Welfare, Helsinki 00271, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland.
James F WilsonCentre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK; MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Brenda W J H PenninxDepartment of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
Diane M BeckerGeneSTAR Research Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bradford B WorrallDepartments of Neurology and Public Health Sciences, University of Virginia Charlottesville, Charlottesville, VA 22908-0394, USA.
Greg GibsonCenter for Integrative Genomics, School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Ronald M KraussChildren's Hospital Oakland Research Institute, Oakland, CA 94609, USA.
Marina CiulloInstitute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy; IRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Gianluigi ZazaRenal Unit, Department of Medicine, Verona University Hospital, Verona 37126, Italy.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion regulation, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, the Netherlands.
Lyle J PalmerSchool of Public Health, University of Adelaide, Adelaide, SA 5000, Australia.
Sarah S MurrayDepartment of Pathology, University of California, San Diego, San Diego, CA 92121, USA.
Peter P PramstallerInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano 39100, Italy; General Central Hospital, Department of Neurology, Bolzano 39100, Italy; Department of Neurology, University of Lübeck, Lübeck 23538, Germany.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze, Florence 50122, Italy.
Joachim HeinrichInstitute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg 85764, Germany; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Comprehensive Pneumology Center Munich, Member DZL, German Center for Lung Research, 81377 Munich, Germany.
Erik IngelssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 751 41, Sweden; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
Liesbeth VandenputDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Pim van der HarstUniversity of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands.
Karl C DeschDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109, USA.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; Imperial College Healthcare NHS Trust, London W12 0HS, UK; MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg 41345, Sweden.
Caroline HaywardMRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
Alan R ShuldinerDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Donna K ArnettUniversity of Kentucky, College of Public Health, Lexington, KY 40508, USA.
Lawrence J BeilinMedical School, University of Western Australia, Perth, WA 6009, Australia.
Antonietta RobinoInstitute for Maternal and Child Health, IRCCS "Burlo Garofolo," Trieste 34140, Italy.
Philippe FroguelCentre National de la Recherche Scientifique UMR 8199, University of Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, FR 3508, 59000 Lille, France; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London SW7 2AZ, UK.
Mario PirastuSupport OU, Institute of Genetic and Biomedic Research, Consiglio Nazionale delle Ricerche, Sassari 7100, Italy.
Tine JessCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg 2200, Denmark.
Wolfgang KoenigGerman Center for Cardiovascular Research, Partner Site Munich Heart Alliance, 80636 Munich, Germany; Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, 80801 Ulm, Germany; Deutsches Herzzentrum München, Technische Universität München, 80636 Munich, Germany.
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6542, USA.
Denis A EvansDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Helena SchmidtDepartment of Neurology, Medical University Graz, Graz 8010, Austria; Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz 8010, Austria.
George Davey SmithMRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
P Eline SlagboomMolecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands.
Gudny EiriksdottirIcelandic Heart Association, Kopavogur 201, Iceland.
Andrew P MorrisWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA; Department of Epidemiology, University of Washington, Seattle, WA 98101, USA; Department of Health Services, University of Washington, Seattle, WA 98195-7660, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA.
Russell P TracyDepartment of Pathology, University of Vermont, Colchester, VT 05405, USA.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Sophie Visvikis-SiestUniversité de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France.
Alex P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA 98101, USA.
Myron GrossDepartment of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Lude FrankeDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Institute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland.
Emelia J BenjaminDepartment of Medicine, Boston University School of Medicine, Boston, MA 02118, USA; National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
Josée DupuisNational Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Abbas DehghanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London W2 1PG, UK. Electronic address: a.dehghan@imperial.ac.uk.
Behrooz Z AlizadehDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands. Electronic address: b.z.alizadeh@umcg.nl.
University Medical Center Groningen · NLLeiden University Medical Center · NLBrigham and Women's Hospital · USCentre for Human Genetics · GBUniversity of Michigan · USUniversity of Verona · ITUniversity of Washington · USErasmus MC · NLEurac Research · ITInserm · FRThe University of Western Australia · AUUniversity of Cambridge · GBUniversity of Helsinki · FIUppsala University · SEStatens Serum Institut · DKUniversitätsmedizin Greifswald · DEUniversity of Maryland, Baltimore · USBoston University · USHelmholtz Zentrum München · DEKarolinska Institutet · SE

Funding

UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2016 to 2020
$12.2M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Targeted Genetic Analysis of T2D and Quantitative TraitsR01DK072193 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2005 to 2026
$11.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genetic epidemiology of rare and regulatory variants for metabolic traitsR01DK093757 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN L. MOHLKE · 2011 to 2026
$8.2M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
The Molecular Genetics of Venous Thromboembolic DiseaseR01HL141399 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DESCH, KARL C · 2018 to 2022
$1.9M
Biotechnology and Biological Sciences Research Council BB/F019394/1Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UP_1605/7Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12015/1Medical Research Council MR/J012165/1Medical Research Council MR/K002414/1Medical Research Council MR/K026992/1NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL141399NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG049638NIA NIH HHS U01 AG052409NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK072193NIDDK NIH HHS R01 DK093757NIDDK NIH HHS U01 DK062370NIH HHS S10 OD020069NINDS NIH HHS R01 NS017950Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersBipolar DisorderBody Mass IndexChildC-Reactive ProteinFemaleGenetic LociGenome-Wide Association StudyHumansInflammationLiverMaleBiomarkersC-Reactive Proteincoronary artery diseaseC-reactive proteinDEPICTgenome-wide association studyinflammationinflammatory disordersMendelian randomizationschizophreniasystem biology

Identifiers

PMID30388399
PMCPMC6218410
OpenAlexW2898901851

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