ArticlePloS one2018
Eosinophilic esophagitis in Japanese patients: A mild and slow-progressing disorder.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Differences in adult eosinophilic esophagitis between Japan and Western countries.Journal of gastroenterology · 2026Review
- Association between serum alder-specific immunoglobulin E positivity and seasonal onset of eosinophilic esophagitis.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Long-term Outcome of Asymptomatic Esophageal Eosinophilia.Gut and liver · 2024Article
- Long-term course of untreated asymptomatic esophageal eosinophilia and minimally symptomatic eosinophilic esophagitis.Endoscopy international open · 2024Article
- Mucosal and Submucosal Thickening of Esophageal Wall Is a Promising Factor in the Development of Symptoms in Eosinophilic Esophagitis.Gut and liver · 2024Review
- Eosinophilic gastrointestinal disorders: a narrative review on clinical perspectives and research gaps in the Asian context.Translational gastroenterology and hepatology · 2024Review
- Clinical presentation and therapeutic outcome of patients with jackhammer esophagus-a multicenter cohort study in Japan.Esophagus : official journal of the Japan Esophageal Society · 2022Article
- Application of Convolutional Neural Networks for Diagnosis of Eosinophilic Esophagitis Based on Endoscopic Imaging.Journal of clinical medicine · 2022Article
- Subjective Symptoms in Patients with Eosinophilic Esophagitis Are Related to Esophageal Wall Thickness and Esophageal Body Pressure.Digestive diseases and sciences · 2021Article
- Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs.Journal of gastroenterology · 2021Observational
- Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles.Journal of clinical biochemistry and nutrition · 2021Article
- Eosinophilic esophagitis: an interdisciplinary clinical problem.Postepy dermatologii i alergologii · 2021Review
- How to approach adult patients with asymptomatic esophageal eosinophilia.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Review
- The "caterpillar sign": a novel endoscopic indicator of eosinophilic esophagitis.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Clinical Features of Esophageal Eosinophilia According to Endoscopic Phenotypes.Internal medicine (Tokyo, Japan) · 2020Article
- Eosinophilic esophagitis with a severe stenosis: report of a Japanese case.Clinical journal of gastroenterology · 2020Article
- Symptom-based diagnostic approach for eosinophilic esophagitis.Journal of gastroenterology · 2020Review
- Risk of progression to eosinophilic esophagitis in patients with asymptomatic esophageal eosinophilia: A retrospective pilot study.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study.Asia Pacific allergy · 2020Article
- Eosinophilic esophagitis: time for clinical practice.Esophagus : official journal of the Japan Esophageal Society · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimAwareness of eosinophilic esophagitis (EoE) has gradually increased in Japan, therefore the characteristics of this disease in the Japanese patient population need to be elucidated. This study aimed to investigate the features of EoE in the Japanese population.
methodsDuring a 2-year period, all gastrointestinal endoscopies were performed with maximum attention being paid to identify EoE through endoscopic findings. Clinical features and findings were analyzed among this population.
resultsAmong a total of 8589 patients (general gastrointestinal endoscopy, performed for evaluation of symptoms or disease follow-up: 3669; medical check-up endoscopy, routinely performed in asymptomatic patients: 4920), 17 patients (0.20%) were diagnosed with esophageal eosinophilia (mean age ± standard deviation: 44±11.9 years; 1 female). Only 6 patients with esophageal eosinophilia were diagnosed by general gastrointestinal endoscopy; among them, 3 patients had dysphagia and 3 were asymptomatic. The remaining 11 patients were diagnosed by medical check-up endoscopy. All patients were treated with a proton pump inhibitor (PPI); 5 were diagnosed with EoE and 12 with PPI responsive esophageal eosinophilia. Chronological endoscopy analysis showed that EoE findings could be observed for a mean of 6.1 years prior to diagnosis, and the disease did not significantly progress in severity.
conclusionsMost Japanese patients with EoE have mild and slowly progressing disease, which can be diagnosed when close attention is paid to the endoscopic findings. Medical check-up endoscopy in Japan could be a great opportunity for the early diagnosis of EoE.
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