ArticlePLoS genetics2018
An investigation of Y chromosome incorporations in 400 species of Drosophila and related genera.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Male sterility in Drosophila mojavensis × D. arizonae hybrids is not caused by gene movements in the Y chromosome.Evolution; international journal of organic evolution · 2025Article
- Sex chromosome evolution in haploid plants: Microchromosomes, disappearing chromosomes, and giant chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2025Review
- Sex chromosome cycle as a mechanism of stable sex determination.Journal of biochemistry · 2024Review
- Cis-regulatory polymorphism at fiz ecdysone oxidase contributes to polygenic evolutionary response to malnutrition in Drosophila.PLoS genetics · 2024Article
- The Drosophila melanogaster Y-linked gene, WDY, is required for sperm to swim in the female reproductive tract.Communications biology · 2024Article
- The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes.PLoS genetics · 2024Article
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- A male-killing gene encoded by a symbiotic virus of Drosophila.Nature communications · 2023Article
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- New Genes in theGenes · 2021Article
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- The timing of genetic degeneration of sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Identification of the sex chromosome system in a sand fly species, Lutzomyia longipalpis s.l.G3 (Bethesda, Md.) · 2021Article
- Complex Evolutionary History of the Y Chromosome in Flies of the Drosophila obscura Species Group.Genome biology and evolution · 2020Article
- Genome Size Evolution Differs BetweenG3 (Bethesda, Md.) · 2019Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
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Abstract
Y chromosomes are widely believed to evolve from a normal autosome through a process of massive gene loss (with preservation of some male genes), shaped by sex-antagonistic selection and complemented by occasional gains of male-related genes. The net result of these processes is a male-specialized chromosome. This might be expected to be an irreversible process, but it was found in 2005 that the Drosophila pseudoobscura Y chromosome was incorporated into an autosome. Y chromosome incorporations have important consequences: a formerly male-restricted chromosome reverts to autosomal inheritance, and the species may shift from an XY/XX to X0/XX sex-chromosome system. In order to assess the frequency and causes of this phenomenon we searched for Y chromosome incorporations in 400 species from Drosophila and related genera. We found one additional large scale event of Y chromosome incorporation, affecting the whole montium subgroup (40 species in our sample); overall 13% of the sampled species (52/400) have Y incorporations. While previous data indicated that after the Y incorporation the ancestral Y disappeared as a free chromosome, the much larger data set analyzed here indicates that a copy of the Y survived as a free chromosome both in montium and pseudoobscura species, and that the current Y of the pseudoobscura lineage results from a fusion between this free Y and the neoY. The 400 species sample also showed that the previously suggested causal connection between X-autosome fusions and Y incorporations is, at best, weak: the new case of Y incorporation (montium) does not have X-autosome fusion, whereas nine independent cases of X-autosome fusions were not followed by Y incorporations. Y incorporation is an underappreciated mechanism affecting Y chromosome evolution; our results show that at least in Drosophila it plays a relevant role and highlight the need of similar studies in other groups.
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