Evidence map›Paper›PMID 30387712›Full record

ArticleeLife2018

Damián Pérez-Mazliah, Peter J Gardner, Edina Schweighoffer, Sarah McLaughlin, Caroline Hosking, Irene Tumwine, Randall S Davis, Alexandre J Potocnik, Victor Lj Tybulewicz, Jean Langhorne

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
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  18. The development and function of CD11cFrontiers in immunology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Damián Pérez-MazliahThe Francis Crick Institute, London, United Kingdom.ORCID http://orcid.org/0000-0002-2156-2585
Peter J GardnerMRC National Institute for Medical Research, London, United Kingdom.ORCID http://orcid.org/0000-0002-4940-2639
Edina SchweighofferThe Francis Crick Institute, London, United Kingdom.
Sarah McLaughlinThe Francis Crick Institute, London, United Kingdom.
Caroline HoskingThe Francis Crick Institute, London, United Kingdom.
Irene TumwineThe Francis Crick Institute, London, United Kingdom.
Randall S DavisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, United States.ORCID http://orcid.org/0000-0003-1906-8219
Alexandre J PotocnikSchool of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom.ORCID http://orcid.org/0000-0002-4730-8593
Victor Lj TybulewiczThe Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0003-2439-0798
Jean LanghorneThe Francis Crick Institute, London, United Kingdom.ORCID https://orcid.org/0000-0002-2257-9733
The Francis Crick Institute · GBUniversity of Alabama at Birmingham · USUniversity of Edinburgh · GB

Funding

Roles of FCRL Molecules in Innate ImmunityR01AI110553 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVIS, RANDALL S · 2015 to 2019
$1.7M
Roles of FCRL Molecules in Innate ImmunityR56AI110553 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVIS, RANDALL S · 2014 to 2014
$368k
Cancer Research UK FC001101 and FC001194Cancer Research UK FC001194Medical Research Council FC001101 and FC001194Medical Research Council FC001194Medical Research Council MC_U117527252NIAID NIH HHS R01 AI110553NIAID NIH HHS R56 AI110553NIH HHS AI110553Wellcome Trust FC001101Wellcome Trust FC001101 and FC001194Wellcome Trust FC001194Wellcome Trust WT101777MA
6 · The paper itself

Abstract

A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite,

Indexed as

Immunologic MemoryAnimalsB-LymphocytesB-Lymphocyte SubsetsFlow CytometryGene Knock-In TechniquesImmunoglobulin GMalariaMerozoite Surface Protein 1Mice, Inbred BALB CMice, Inbred C57BLPlasmodium chabaudiRodent DiseasesImmunoglobulin GMerozoite Surface Protein 1age-associated B cellsatypical memory B cellsFCRL5immunologyinfectious diseaseinflammationmalariamicrobiologymosquitomousePlasmodium

Identifiers

PMID30387712
PMCPMC6242553
OpenAlexW2899390811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.