Evidence map›Paper›PMID 30387550›Full record

ArticleJournal of medical radiation sciences2019

The role of volumetric modulated arc therapy (VMAT) in gynaecological radiation therapy: A dosimetric comparison of intensity modulated radiation therapy versus VMAT.

Penelope Knapp, Belinda Eva, Gemma Reseigh, Adrian Gibbs, Lucy Sim, Tiffany Daly, Judith Cox, Anne Bernard

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of medical radiation sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  3. Morbidity of radical surgery and postoperative radiotherapy in cervical cancer.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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  11. Outcome and toxicity of chemoradiation using volumetric modulated arc therapy followed by 3D image-guided brachytherapy for cervical cancer: Vietnam National Cancer Hospital experience.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Penelope KnappRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-7695-907X
Belinda EvaRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Gemma ReseighRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Adrian GibbsRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Lucy SimRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Tiffany DalyRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Judith CoxRadiation Oncology Princess, Alexandra Hospital Raymond Terrace, Cancer Services, Metro South Health Service District, South Brisbane, Queensland, Australia.
Anne BernardQFAB Bioinformatics, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Princess Alexandra Hospital · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFor gynaecological cancers, volumetric modulated arc therapy (VMAT) offers comparable plan quality with shorter treatment delivery times when compared to intensity modulated radiation therapy (IMRT).

methodsThe clinical IMRT plans of twenty gynaecological cancer patients were compared with a retrospectively generated VMAT plan. Planning target volume (PTV) metrics compared were D95 > 99%, homogeneity index, and conformity index. Organs at risk (OAR) doses compared were bladder V45 < 35%, bowel V40 < 30%, femoral head and neck (FHN) V30 < 50%, V44 < 35% and V44 < 5%. Plan quality was also assessed by comparing the monitor units (MU), treatment time and the patient-specific quality assurance results.

resultsVMAT and IMRT resulted in comparable PTV coverage with D95 values of 98.92% ± 0.69% and 98.91% ± 1.43% respectively, and homogeneity index values of 0.08 ± 0.02 (VMAT) and 0.08 ± 0.03 (IMRT). The conformity index for VMAT was 0.93 ± 0.04 and IMRT 0.85 ± 0.06 (P < 0.001). For the bowel tolerance (40 Gy < 30%) VMAT resulted in 22.39% ± 12.5% compared to 28.8% ± 16.78% for IMRT, with bladder and FHN VMAT doses also lower. VMAT MU were 694.35 ± 126.56 compared to 606.8 ± 96.16 for IMRT (P < 0.01). Treatment times of 6.6 ± 0.82 min and 2.47 ± 0.35 min were achieved for IMRT and VMAT respectively.

conclusionVMAT showed improvements in sparing OAR compared to IMRT. Target volume coverage with VMAT was equivalent or better than that of IMRT. These results in conjunction with the confirmed shorter treatment delivery time, have led to the development and implementation of a clinical protocol.

Indexed as

Radiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedDose Fractionation, RadiationFemaleGenital Neoplasms, FemaleHumansOrgans at RiskRadiometryRetrospective StudiesDosimetrygynaecological cancerintensity modulated radiation therapyvolumetric arc therapy

Identifiers

PMID30387550
PMCPMC6399190
OpenAlexW2898988164

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.