ArticlePharmaceutical biology2018
Green synthesis of selenium nanoparticles with extract of hawthorn fruit induced HepG2 cells apoptosis.
Article in Pharmaceutical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 134 citations in OpenAlex.
- Green Synthesized Selenium Nanoparticles Enhance Postharvest Nutritional Quality and Anti-Browning Capacity of Pleurotus ostreatus (Oyster Mushroom).Journal of food science · 2026Article
- Development and Characterization of a Guar Gum Bionanocomposite Loaded with Biogenic Selenium Nanoparticles and Its Cytotoxic Evaluation.Gels (Basel, Switzerland) · 2026Article
- Phytochemical-mediated green synthesis of selenium nanoparticles using Catharanthus roseus and their physicochemical characterization, biological evaluation, and molecular docking analysis.Scientific reports · 2026Article
- Selenium nanoparticles: Eco-friendly synthesis, biological activities and biomedical applications - A comprehensive review.Materials today. Bio · 2026Review
- Biosynthesis of selenium nanoparticles by Aloe vera leaf extract and its biomedical applications.Discover nano · 2026Article
- Eco-friendly synthesis of Balanites aegyptiaca-derived selenium nanoparticles: extract and assessment of their anticancer, antimicrobial, cytogenetic and molecular docking insights.Scientific reports · 2026Article
- The anticancer effect of γ-irradiation synthesized selenium nanoparticles stabilized in β-glucan on HepG2 cell proliferationNanoscale advances · 2026Article
- Phytosynthesis of Selenium Nanoparticles fromAnti-cancer agents in medicinal chemistry · 2026Article
- From Tradition to Innovation: Pinellia ternata Extracts Stabilized Selenium Nanoparticles for Enhanced Bioactivity.Biological trace element research · 2025Article
- Three bacterial strains efficiently reduce selenite to selenium nanoparticles in cell membranes.BMC microbiology · 2025Article
- Review
- Uncovering the potential of biofabricated Ananas comosus peel selenium nanoparticles for antibacterial, antibiofilm, suppression of virulence genes (can and LuxS), anticancer, and antioxidant properties.BMC biotechnology · 2025Article
- Antioxidant and Anticancer Activities of Bio-Synthesized Selenium Nanoparticles by Escherichia coli.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- In vitro and in vivo studies of selenium nanoparticles coated bacterial polysaccharide as anti-lung cancer agents.Microbial cell factories · 2024Article
- Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance.Chinese medicine · 2024Review
- Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer.Biomolecules · 2024Review
- Molecular Mechanisms of the Therapeutic Effect of Selenium Nanoparticles in Hepatocellular Carcinoma.Cells · 2024Review
- Recent Advances in Biomedical Nanotechnology Related to Natural Products.Current pharmaceutical biotechnology · 2024Review
- Hawthorn with "homology of medicine and food": a review of anticancer effects and mechanisms.Frontiers in pharmacology · 2024Review
- Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextSelenium nanoparticles (SeNPs) have attracted worldwide attention due to their unique properties and potential bioactivities. Considering that hawthorn is both a traditional medicine and a common edible food, hawthorn fruit extract (HE) was chosen as a reductant to prepare SeNPs.
objectiveSeNPs were synthesized by using an aqueous HE as a reductant and stabilizer. The antitumor activities and potential mechanisms of SeNPs were explored by using a series of cellular assays. MATERIALS AND
methodsThe HE mediated SeNPs (HE-SeNPs) were examined using various characterisation methods. The cytotoxicity was measured against HepG2 cells after treated with 0, 5, 10 and 20 μg/mL of HE-SeNPs for 24 h. Annexin V-FITC/PI staining analysis was performed to observe the apoptosis of HepG2 cells. Additionally, mitochondrial membrane potential (MMP), intracellular reactive oxygen species (ROS) levels were evaluated. Finally, the protein expression levels of caspase-9 and Bcl-2 were identified by Western blot.
resultsThe mono-dispersed and stable SeNPs were prepared with an average size of 113 nm. HE-SeNPs showed obvious antitumor activities towards HepG2 cells with an IC DISCUSSION AND
conclusionsHE-SeNPs induced intracellular oxidative stress and mitochondrial dysfunction to initiate HepG2 cell apoptosis through the mitochondrial pathway. Therefore, HE-SeNPs may be a candidate for further evaluation as a chemotherapeutic agent for human liver cancer.
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