ArticleJournal of Zhejiang University. Science. B
Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate.
Article in Journal of Zhejiang University. Science. B. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Therapeutic methods and effect on keloid and hypertrophic scars: a systematic review.Frontiers in medicine · 2026Pooled it
- Hyperbaric Oxygen Therapy in Aesthetic Medicine and Anti-Aging: A Systematic Review.Aesthetic plastic surgery · 2025Pooled it
- Hyperbaric oxygen therapy for late radiation tissue injury.The Cochrane database of systematic reviews · 2023Pooled it
- Keloid treatments: an evidence-based systematic review of recent advances.Systematic reviews · 2023Pooled it
- The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis.Biomolecules · 2021Pooled it
- Impact of hyperbaric oxygenation therapy (HBOT) on renal function in human.Scientific reports · 2025Article
- Effects of exosomes from human dental pulp stem cells on the biological behavior of human fibroblasts.Scientific reports · 2025Article
- Comparative Efficacy of Silicone Sheets and Hyperbaric Oxygen Therapy in Post-Surgical Scar Prevention: A Prospective Observational Study.International journal of medical sciences · 2025Observational
- Hyperbaric oxygen and steroids for preventing stricture after large esophageal endoscopic submucosal dissection.Endoscopy international open · 2025Article
- Apocynin and Hyperbaric Oxygen Therapy Improve Renal Function and Structure in an Animal Model of CKD.Biomedicines · 2024Article
- Roles of MMP-2 and MMP-9 and their associated molecules in the pathogenesis of keloids: a comprehensive review.Frontiers in pharmacology · 2024Review
- Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.Burns & trauma · 2024Article
- The Mechanisms of Action of Hyperbaric Oxygen in Restoring Host Homeostasis during Sepsis.Biomolecules · 2023Review
- Review
- Article
- Effect of artificial skin membrane on the expression of miR-155 and miR-506-3p in patients with second-degree burns.Journal of clinical laboratory analysis · 2022Article
- Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study.Journal of Zhejiang University. Science. B · 2022Article
- Clinical Observation of Subepidermal Vascular Network Flaps in Keloid Patients.Aesthetic plastic surgery · 2022Article
- Immune-related gene expression in skin, inflamed and keloid tissue from patients with keloids.Oncology letters · 2022Article
- Small extracellular vesicles from mesenchymal stem cells: A potential Weapon for chronic non-healing wound treatment.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveKeloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy.
methods(1) A total of 240 patients were randomly divided into two groups. Patients in the HBOT group (O group) received HBOT after surgical excision and radiotherapy. Patients in the other group were treated with only surgical excision and radiotherapy (K group). (2) Scar tissue from recurrent patients was collected after a second operation. Hematoxylin and eosin (H&E) staining was used to observe keloid morphology. Certain inflammatory factors (interleukin-6 (IL-6), hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and vascular endothelial growth factor (VEGF)) were measured using immunohistochemical staining.
results(1) The recurrence rate of the O group (5.97%) was significantly lower than that of the K group (14.15%), P<0.05. Moreover, patients in the O group reported greater satisfaction than those in the K group (P<0.05). (2) Compared with the recurrent scar tissue of the K group, the expression levels of the inflammatory factors were lower in the recurrent scar tissue of the O group.
conclusionsAdjunctive HBOT effectively reduces the keloid recurrence rate after surgical excision and radiotherapy by improving the oxygen level of the tissue and alleviating the inflammatory process.
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