Evidence map›Paper›PMID 30387149›Full record

ArticleJournal of cellular physiology2019

G Protein α Subunit 14 Mediates Fibroblast Growth Factor 2-Induced Cellular Responses in Human Endothelial Cells.

Qing-Yun Zou, Ying-Jie Zhao, Chi Zhou, Ai-Xia Liu, Xin-Qi Zhong, Qin Yan, Yan Li, Fu-Xian Yi, Ian M Bird, Jing Zheng

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. FilaggrinFrontiers in genetics · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Endothelial CaInternational journal of molecular sciences · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Qing-Yun ZouDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Ying-Jie ZhaoDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Chi ZhouDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Ai-Xia LiuDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Xin-Qi ZhongDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Qin YanDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Yan LiDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Fu-Xian YiDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Ian M BirdDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.
Jing ZhengDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-2224-2372
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Unified Cellular and Molecular CoreP01HD038843 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI ZHENG, JING · 2001 to 2017
$14.4M
NCATS NIH HHS UL1 TR002373NICHD NIH HHS P01 HD038843
6 · The paper itself

Abstract

During pregnancy, a tremendous increase in fetoplacental angiogenesis is associated with elevated blood flow. Aberrant fetoplacental vascular function may lead to pregnancy complications including pre-eclampsia. Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) are crucial regulators of fetoplacental endothelial function. G protein α subunit 14 (GNA14), a member of Gαq/11 subfamily is involved in mediating hypertensive diseases and tumor vascularization. However, little is known about roles of GNA14 in mediating the FGF2- and VEGFA-induced fetoplacental endothelial function. Using human umbilical vein endothelial cells (HUVECs) cultured under physiological chronic low oxygen (3% O

Indexed as

Capillary PermeabilityCell MovementCells, CulturedFemaleFibroblast Growth Factor 2GTP-Binding Protein alpha Subunits, Gq-G11HumansHuman Umbilical Vein Endothelial CellsNeovascularization, PhysiologicPlacentaPregnancyFibroblast Growth Factor 2GNA14 protein, humanGTP-Binding Protein alpha Subunits, Gq-G11angiogenesisendothelial cellsFGF2GNA14VEGFA

Identifiers

PMID30387149
PMCPMC6426666
OpenAlexW2898853962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.