Evidence map›Paper›PMID 30387140›Full record

ArticleJournal of cellular physiology2019

PU.1 and epigenetic signals modulate 1,25-dihydroxyvitamin D

Ran Wei, Puneet Dhawan, Robert A Baiocchi, Ki-Yoon Kim, Sylvia Christakos

Open access · greenAbstract read
In one paragraph

Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ran WeiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, New Jersey.
Puneet DhawanDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, New Jersey.
Robert A BaiocchiDepartment of Internal Medicine, Ohio State University, Columbus, Ohio.
Ki-Yoon KimDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, New Jersey.
Sylvia ChristakosDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers, New Jersey Medical School, The State University of New Jersey, Newark, New Jersey.ORCID 0000-0001-9148-5549
Rutgers, The State University of New Jersey · USThe Ohio State University · US

Funding

Vitamin D and Innate Immunity in Respiratory InfectionsR21AI100379 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S, DIAMOND, GILL · 2012 to 2013
$431k
The in vivo effect of vitamin D on Mycobacterium tuberculosis infectionR21AI121621 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI CHRISTAKOS, SYLVIA S, SALGAME, PADMINI · 2016 to 2017
$420k
NIAID NIH HHS R21 AI100379NIAID NIH HHS R21 AI121621
6 · The paper itself

Abstract

LL-37, the only known human cathelicidin which is encoded by the human antimicrobial peptide (CAMP) gene, plays a critical role in protection against bacterial infection. We previously demonstrated that cathelicidin is induced by 1,25-dihydroxyvitamin D

Indexed as

AcetylationAntimicrobial Cationic PeptidesCathelicidinsCCAAT-Enhancer-Binding ProteinsChromatin Assembly and DisassemblyEpigenesis, GeneticEpithelial CellsGene Expression RegulationHEK293 CellsHumansLungProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Receptors, CalcitriolTrans-ActivatorsTranscription Factors1,25-dihydroxyvitamin DAntimicrobial Cationic PeptidesCathelicidinsCCAAT-Enhancer-Binding ProteinsCEBPA protein, humanProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Receptors, CalcitriolTrans-ActivatorsTranscription FactorsVitamin D125-dihydroxyvitamin D3Brahma-related gene 1cathelicidinhistone acetylationprotein arginine methyltransferase 5PU.1

Identifiers

PMID30387140
PMCPMC6814306
OpenAlexW2899025988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.