ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Early 7-day supplemental parenteral nutrition improves body composition and muscle strength in hypophagic cancer patients at nutritional risk.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02828150 (Integrative Parenteral Nutrition in Hospitalized, Malnourished, Hypophagic Cancer Patients With Contraindication to Enteral Nutrition), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integrative Parenteral Nutrition in Hospitalized, Malnourished, Hypophagic Cancer Patients With Contraindication to Enteral Nutrition
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Pooled it
- Pooled it
- Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy.Cancer medicine · 2019Trial
- Body composition analysis and handgrip strength as predictors of 12-month mortality in hospitalized adults receiving parenteral nutrition: A descriptive cohort study.JPEN. Journal of parenteral and enteral nutrition · 2026Observational
- Early versus late supplemental parenteral nutrition in gastrointestinal cancer patients undergoing major abdominal surgery: 5-year outcomes from a randomized clinical trial.International journal of surgery (London, England) · 2026Article
- Early enteral nutrition combined with supplemental parenteral nutrition vs. total parenteral nutrition after pancreaticoduodenectomy: a retrospective and propensity score-matched analysis of postoperative complications.Frontiers in nutrition · 2025Article
- Optimizing clinical nutrition practices: impact of a formulary prescription-based nutrition therapy protocol in surgical patients.Frontiers in nutrition · 2025Article
- The effect of preoperative supplementary parenteral nutrition on nutrition and inflammation in gastric cancer patients.Discover oncology · 2024Article
- Bioimpedance-derived body composition parameters predict mortality and dose-limiting toxicity: the multicenter ONCO-BIVA study.ESMO open · 2024Observational
- Article
- Lack of clinical benefit from preoperative short-term parenteral nutrition on the clinical prognosis of patients treated with radical gastrectomy for gastric cancer: a two-center retrospective study based on propensity score matching analysis.Journal of gastrointestinal oncology · 2024Article
- Sarcopenia negatively affects postoperative short-term outcomes of patients with non-cirrhosis liver cancer.BMC cancer · 2023Article
- Nascent to novel methods to evaluate malnutrition and frailty in the surgical patient.JPEN. Journal of parenteral and enteral nutrition · 2023Review
- Effect of standard nutritional support therapy based on nutritional risk screening on post-operative nutritional status and quality of life in patients with glioma.American journal of translational research · 2023Article
- Exploration of an objective and simple index as the outcome of nutrition support for elderly patients and identification of risk factors.European journal of clinical nutrition · 2022Observational
- Clinical and economic value of oral nutrition supplements in patients with cancer: a position paper from the Survivorship Care and Nutritional Support Working Group of Alliance Against Cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Review
- Associations between hydration status, body composition, sociodemographic and lifestyle factors in the general population: a cross-sectional study.BMC public health · 2022Article
- SINPE Position Paper on the use of home parenteral nutrition in cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Review
- A European survey on the practice of nutritional interventions in head-neck cancer patients undergoing curative treatment with radio(chemo)therapy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Supplemental parenteral nutrition in cancer care: why, who, when.Therapeutic advances in medical oncology · 2022Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe international guidelines recommend the use of supplemental parenteral nutrition (SPN) in cancer patients when they are malnourished and hypophagic and where enteral nutrition is not feasible. However, there are limited data on the short-term effects of SPN in this patient population.
methodsThe aim of this bicentric single-arm clinical trial (NCT02828150) was to evaluate the effects of early 7-day SPN on bioimpedance vectorial analysis (BIVA)-derived body composition, handgrip strength (HG), and serum prealbumin (PAB) in 131 hypophagic, hospitalized cancer patients at nutritional risk, with contraindications for enteral nutrition.
resultsOne hundred eighteen patients (90.1%) completed the 7-day SPN support regimen and 102 of them (86.4%) were in advanced disease stage. SPN induced a significant improvement of phase angle (PhA, + 0.25 [95% CI 0.11, 0.39]; p = 0.001), standardized phase angle (SPA, + 0.33 [95% CI 0.13, 0.53]; p = 0.002), HG (+ 2.1 kg -95% CI 1.30, 2.81]; p < 0.001), and PAB (+ 3.8 mg/dL [95% CI 2.1, 5.6]; p < 0.001). In multivariable analysis, the effects on BIVA parameters were more pronounced in patients (N = 90, 76.3%) in whom estimated protein and calorie requirements were both satisfied (adjusted difference: PhA, + 0.39 [95% CI 0.04, 0.73]; p = 0.030; SPA, + 0.62 [95% CI 0.16, 1.09]; p = 0.009). No significant changes in hydration status were detected and no severe metabolic or other complications occurred.
conclusionsEarly 7-day SPN resulted in improved body composition, HG and PAB levels in hypophagic, and hospitalized cancer patients at nutritional risk in the absence of any relevant clinical complications. Further trials, aimed at verifying the efficacy of this early nutritional intervention on mid- and long-term primary clinical endpoints in specific cancer types, are warranted.
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