Evidence map›Paper›PMID 30386951›Full record

Trial reportAnnals of biomedical engineering2019

Ankle Rotation and Muscle Loading Effects on the Calcaneal Tendon Moment Arm: An In Vivo Imaging and Modeling Study.

Jason R Franz, Ashish Khanchandani, Hannah McKenny, William H Clark

Abstract readClinical Trial
In one paragraph

Trial report in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Simultaneous Quantification of Ankle, Muscle, and Tendon Impedance in Humans.IEEE transactions on bio-medical engineering · 2022
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason R FranzJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 152 MacNider Hall, Chapel Hill, NC, 27599, USA. jrfranz@email.unc.edu.ORCID http://orcid.org/0000-0001-9523-9708
Ashish KhanchandaniDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hannah McKennyJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 152 MacNider Hall, Chapel Hill, NC, 27599, USA.
William H ClarkJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, 152 MacNider Hall, Chapel Hill, NC, 27599, USA.

Funding

Tech-DevelopmentP2CHD065690 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2015 to 2019
$5.4M
Influence of Age-Related Changes in Tendon on Motor PerformanceR01AG051748 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BLEMKER, SILVIA SALINAS, THELEN, DARRYL G · 2016 to 2020
$1.8M
National Center for Simulation in Rehabilitation Research UnlistedNational Institutes of Health R01AG051748NIA NIH HHS R01 AG051748NICHD NIH HHS P2C HD065690
6 · The paper itself

Abstract

In this combined in vivo and computational modeling study, we tested the central hypothesis that ankle joint rotation and triceps surae muscle loading have independent and combinatory effects on the calcaneal (i.e., Achilles) tendon moment arm (CTma) that are not fully captured in contemporary musculoskeletal models of human movement. We used motion capture guided ultrasound imaging to estimate instantaneous variations in the CTma during a series of isometric and isotonic contractions compared to predictions from scaled, lower extremity computational models. As hypothesized, we found that muscle loading: (i) independently increased the CTma by up to 8% and (ii) attenuated the effects of ankle joint rotation, the latter likely through changes in tendon slack and tendon curvature. Neglecting the effects of triceps surae muscle loading in lower extremity models led to an underestimation of the CTma, on average, particularly in plantarflexion when those effects were most prominent. We also found little agreement between in vivo estimates and model predictions on an individual subject by subject basis, alluding to unaccounted for variation in anatomical morphology and thus fundamental limitations in model scaling. Together, these findings contribute to improving our understanding of the physiology of ankle moment and power generation and novel opportunities for model development.

Indexed as

Achilles TendonAnkle JointDiagnostic ImagingModels, BiologicalMuscle, SkeletalRotationAdultFemaleHumansIsometric ContractionIsotonic ContractionMaleMovementWeight-BearingDynamometryOpenSimPlantarflexorTriceps suraeUltrasound

Identifiers

PMID30386951
PMCPMC6344261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.