ArticlePharmaceutical research2018
Formulating Inhalable Dry Powders Using Two-Fluid and Three-Fluid Nozzle Spray Drying.
Article in Pharmaceutical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Engineering of OHet72 Nanocrystals into Nanostructured Microparticles for Pulmonary Delivery of a Novel Antitubercular Drug Candidate.Pharmaceutics · 2026Article
- Design and Production of Respirable Effervescent Microparticles to Enhance Drug Penetration Through Lung Mucus.Pharmaceutics · 2026Article
- Spray drying Eudragit® E-PO with acetaminophen using 2- and 3-fluid nozzles for taste masking.International journal of pharmaceutics · 2024Article
- Freeze-drying of bupivacaine lipospheres: preparation, characterization, and evaluation of anti-microbial properties.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- In Vitro and In Vivo Evaluation of Inhalable Ciprofloxacin Sustained Release Formulations.Pharmaceutics · 2023Article
- Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application.Pharmaceutics · 2023Article
- Development of engineered probiotics with tailored functional properties and their application in food science.Food science and biotechnology · 2023Review
- Development of Inhalable Spray Dried Nitrofurantoin Formulations for the Treatment of Emphysema.Pharmaceutics · 2022Article
- Spray freeze drying to solidify Nanosuspension of Cefixime into inhalable microparticles.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Article
- Surface Composition and Aerosolization Stability of an Inhalable Combinational Powder Formulation Spray Dried Using a Three-Fluid Nozzle.Pharmaceutical research · 2020Article
- Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe spray drying process is widely applied for pharmaceutical particle engineering. The purpose of this study was to investigate advantages and disadvantages of two-fluid nozzle and three-fluid nozzle spray drying processes to formulate inhalable dry powders.
methodsBudesonide nanocomposite microparticles (BNMs) were prepared by co-spray drying of budesonide nanocrystals suspended in an aqueous mannitol solution by using a two-fluid nozzle spray drying process. Budesonide-mannitol microparticles (BMMs) were prepared by concomitant spray drying of a budesonide solution and an aqueous mannitol solution using a spray drier equipped with a three-fluid nozzle. The resulting dry powders were characterized by using X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA) and Raman microscopy. A Next Generation Impactor was used to evaluate the aerodynamic performance of the dry powders.
resultsXRPD and DMA results showed that budesonide remained crystalline in the BNMs, whereas budesonide was amorphous in the BMMs. Spray drying of mannitol into microparticles resulted in a crystalline transformation of mannitol, evident from XRPD, DSC and Raman spectroscopy analyses. Both BMMs and BNMs displayed a faster dissolution rate than bulk budesonide. The yield of BNMs was higher than that of BMMs. The mass ratio between budesonide and mannitol was preserved in the BNMs, whereas the mass ratio in the BMMs was higher than the theoretical ratio.
conclusionsSpray drying is an enabling technique for preparation of budesonide amorphous solid dispersions and nanocrystal-embedded microparticles. Two-fluid nozzle spray drying is superior to three-fluid nozzle spray drying in terms of yield.
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