ReviewPreventive nutrition and food science2018
The Fluoride Debate: The Pros and Cons of Fluoridation.
Review in Preventive nutrition and food science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- The Relationship between Fluoride Exposure and Cognitive Outcomes from Gestation to Adulthood-A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Individual, Family, and Socioeconomic Contributors to Dental Caries in Children from Low- and Middle-Income Countries.International journal of environmental research and public health · 2022Pooled it
- Developing an integrated multilevel model of uncertainty in health care: a qualitative systematic review and thematic synthesis.BMJ global health · 2022Pooled it
- Effects of calcium-containing solutions on fluorescence-detectable plaque area and enamel mineral volume: an in vitro and exploratory clinical study.BMC oral health · 2026Trial
- Arginine Dentifrices and Childhood Caries Prevention: A Randomized Clinical Trial.JDR clinical and translational research · 2026Trial
- A Phase 1 Trial to Evaluate the Relationship Between Fluoride Intake and Urinary Fluoride Excretion in Healthy Participants.Journal of clinical pharmacology · 2022Trial
- Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK-8507, an Investigational, Oral, Once-Weekly Nonnucleoside Reverse Transcriptase Inhibitor.Journal of clinical pharmacology · 2022Trial
- Biofilm formation following chitosan-based varnish or chlorhexidine-fluoride varnish application in patients undergoing fixed orthodontic treatment: a double blinded randomised controlled trial.BMC oral health · 2021Trial
- Mechanistic Insights into metformin's neuroprotective effects against drug-induced neurotoxicity.Metabolic brain disease · 2026Review
- Sociodemographic Determinants of Knowledge and Risk Perception Regarding Community Fluoridation: A Cross-Sectional Study in Iași, Romania.Epidemiologia (Basel, Switzerland) · 2026Article
- Cleft lip and palate are associated with a higher prevalence of molar-incisor hypomineralisation: a cross-sectional study with a comparison group.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Drugstore or discount? A study on fluoride, pH and acidity of commercial mouthwashes in Riyadh, Saudi Arabia.Frontiers in oral health · 2026Article
- Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.Clinical, cosmetic and investigational dentistry · 2026Review
- Sustainable Fluoride Determination in Selected Infant Juices Available on the Serbian Market: Health Risk Assessment.Biological trace element research · 2025Article
- Fluoride in Dental Caries Prevention and Treatment: Mechanisms, Clinical Evidence, and Public Health Perspectives.Healthcare (Basel, Switzerland) · 2025Review
- How the public's knowledge, attitudes, and practice intersect with scientific evidence about fluoride.Current problems in pediatric and adolescent health care · 2025Article
- Maternal Urinary Fluoride Levels of a Large Pregnancy Cohort in the United States: Findings from the ADORE Study.Environmental health perspectives · 2025Article
- Evaluation of Broccoli Extract for Enhancing Primary Tooth Enamel Microhardness: An In Vitro Study.Health science reports · 2025Article
- Exploring the protective role of metformin and dehydrozingerone in sodium fluoride-induced neurotoxicity: evidence from prenatal rat models.3 Biotech · 2025Article
- Performance of large language models in fluoride-related dental knowledge: a comparative evaluation study of ChatGPT-4, Claude 3.5 Sonnet, Copilot, and Grok 3.Journal of Yeungnam medical science · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluoride is one of the most abundant elements found in nature. Water is the major dietary source of fluoride. The only known association with low fluoride intake is the risk of dental caries. Initially, fluoride was considered beneficial when given systemically during tooth development, but later research has shown the importance and the advantages of its topical effects in the prevention or treatment of dental caries and tooth decay. Water fluoridation was once heralded as one of the best public health achievements in the twentieth century. Since this practice is not feasible or cost effective in many regions, especially rural areas, researchers and policy makers have explored other methods of introducing fluoride to the general population such as adding fluoride to milk and table salt. Lately, major concerns about excessive fluoride intake and related toxicity were raised worldwide, leading several countries to ban fluoridation. Health-care professionals and the public need guidance regarding the debate around fluoridation. This paper reviews the different aspects of fluoridation, their effectiveness in dental caries prevention and their risks. It was performed in the PubMed and the Google Scholar databases in January 2018 without limitation as to the publication period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.