ReviewFrontiers in oncology2018
Radiation-Induced Sarcoma of the Head and Neck: A Review of the Literature.
Review in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinicopathologic Analysis of Sarcomas in the Oral and Maxillofacial Region: A Systematic Review.Oral diseases · 2026Pooled it
- Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review.Advances in therapy · 2021Pooled it
- Radiation Associated Undifferentiated Pleomorphic Sarcoma of the Neck 2 Decades After External Beam Radiation for Medullary Thyroid Carcinoma: A Case Report and Literature Review.The American journal of case reports · 2026Review
- Radiation-Induced Malignancies of the Head and Neck: A Single-Center Population Study and Survival Outcomes.Current oncology (Toronto, Ont.) · 2026Article
- Case Report on Radiation-Induced Osteosarcoma of the Nasopharynx: Unmasking the Aftermath.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Chronic Invasive Fungal Sinusitis Mimicking Malignancy Post-Radiotherapy: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- [Radiation-induced sarcoma in patients with nasopharyngeal carcinoma: a single-institution retrospective study].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Article
- Survival analysis and prognostic model establishment of secondary osteosarcoma: a SEER-based study.Annals of medicine and surgery (2012) · 2024Article
- Review
- Radiation-Induced Oropharyngeal Squamous Cell Carcinoma: Case Report and Review of the Literature.Current oncology (Toronto, Ont.) · 2023Review
- When Radiation Therapy Becomes a Foe: A Rare Case of Radiation-Induced Angiosarcoma of Head and Neck.Cureus · 2023Article
- Radiation-induced Sarcoma in the Head and Neck: Clinical, Imaging, Histopathological, and Therapeutic Characterization.Plastic and reconstructive surgery. Global open · 2022Article
- Risk factors of secondary cancer in nasopharyngeal carcinoma patients after radiotherapy.Journal of Cancer · 2022Article
- Radiation-induced sarcomas: A single referral cancer center experience and literature review.Frontiers in oncology · 2022Article
- Genetic alteration and clonal evolution of primary glioblastoma into secondary gliosarcoma.CNS neuroscience & therapeutics · 2021Article
- Pathological and genomic phenotype of second neuroendocrine carcinoma during long-term follow-up after radical radiotherapy for nasopharyngeal carcinoma.Radiation oncology (London, England) · 2021Article
- Head and neck adult-type soft tissues sarcomas: survival analysis and comparison between the last two editions of the TNM staging system.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe.Insights into imaging · 2021Review
- Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma.Case reports in genetics · 2021Article
- Radiation-induced sarcoma presenting as a gluteal abscess: a diagnostic and therapeutic challenge.BMJ case reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decades, radiotherapy (RT) has become one of the cornerstones in the treatment of head and neck (HN) malignancies and has paralleled an increase in long-term patient survival. This lead to a concomitant increase in the incidence of radiation-induced sarcomas (RIS) of the irradiated field, with an annual rate up to 0.17%. The new techniques of irradiation do not seem to influence the risk of RIS of the HN (RISHN), which mainly develop within the middle-dose field. The median latency of RISHN after RT is 10-12 years and osteosarcoma is the most represented histotype, even though there is a high variability in time of occurrence and histological features observed. There is no clear evidence of predisposing factors for RISHN, and genetic findings so far have not revealed any common mutation. Early clinical diagnosis of RISHN is challenging, since it usually occurs within fibrotic and hardened tissues, while radiological findings are not pathognomonic and able to differentiate them from other neoplastic entities. Given the highly aggressive behavior of RISHN and its poor sensitivity to chemotherapy, radical surgery is the most important prognostic factor and the only curative option at present. Nevertheless, the anatomy of the HN district and the infiltrative nature of RIS do not always allow radical intervention. Therefore, a wise integration with systemic therapy and, when feasible, re-irradiation should be performed. Future findings in the genomic features of RISHN will be crucial to identify a possible sensitivity to specific drugs in order to optimize a multimodal treatment that will be ideally complementary to surgery and re-irradiation.
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