ArticleJournal of materials chemistry. B2018
Antibacterial and Potentiation Properties of Charge-Optimized Polyrotaxanes for Combating Opportunistic Bacteria.
Article in Journal of materials chemistry. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics.ACS infectious diseases · 2022Review
- Antibacterial and Biofilm-Eradicating Activities of pH-Responsive Vesicles againstMolecular pharmaceutics · 2022Article
- ROS-sensitive micelles for controlled delivery of antibiotics to combat intracellularJournal of materials chemistry. B · 2021Article
- Synthesis and evaluation of an amphiphilic deferoxamine:gallium-conjugated cationic random copolymer against a murine wound healing infection model of Pseudomonas aeruginosa.Acta biomaterialia · 2021Article
- On the Nonspecific Resistance in Burn Injury: Pathophysiological Aspects (Review).Sovremennye tekhnologii v meditsine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Bacteria are now becoming more resistant to most conventional antibiotics. Approaches for the treatment of multidrug-resistant bacterial infections are urgently required. Cationic polymers have broad-spectrum antibacterial activity but can also induce non-specific damage to mammalian cells. Herein, we report on the design of cationic polyrotaxanes (cPRs) with variable charge densities. cPRs were prepared by conjugating neutral ethanolamine and cationic ethylenediamine at various ratios onto threaded alpha-cyclodextrins and their antimicrobial and cytocompatible properties were investigated in vitro. In contact with Gram-negative bacteria, cPRs can disrupt the bacterial outer membrane integrity via electrostatic interactions and penetrate into the cytosol. The ability of cPRs to serve as potentiators at sub-MIC concentrations, to enhance the permeability and activity of poorly permeable antibiotics such as vancomycin, erythromycin and rifampicin, was also investigated against Gram-negative
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.