ArticleGenes and environment : the official journal of the Japanese Environmental Mutagen Society2018
Analysis of large deletion mutations induced by abasic site analog in human cells.
Article in Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antisense Versus Antigene in the Computer-Aided Design of Triplex-Forming Oligonucleotides (TFO): Insights from a Dual-Method Review, Combining Bibliometric and Systematic Review.International journal of molecular sciences · 2025Pooled it
- Urinary biomarkers for secondhand smoke and heated tobacco products exposure.Journal of clinical biochemistry and nutrition · 2021Article
- Effects of smoking cessation on biological monitoring markers in urine.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- New indicatorGenes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020Article
- Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbasic sites are formed spontaneously and by nucleobase chemical modifications and base excision repair. A chemically stable abasic site analog was site-specifically introduced into replicable plasmid DNAs, which were transfected into human U2OS cells. The amplified DNAs were recovered from the cells and used for the transformation of a bacterial indicator strain.
resultsLarge deletion mutations were induced by the analog, in addition to point mutations at the modified site. No apparent sequence homology at the deletion junctions was found.
conclusionThese results suggested that the large deletions induced by the abasic site analog are formed by homology-independent events.
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Registered trials
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