Evidence map›Paper›PMID 30386406›Full record

ArticleNutrition & metabolism2018

Bariatric surgery reduces CD36-bearing microvesicles of endothelial and monocyte origin.

Jaco Botha, Morten Hjuler Nielsen, Maja Høegh Christensen, Henrik Vestergaard, Aase Handberg

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Nutrition & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06881706 (Relationship Between Biochemical and Anthropometric Variables and CD36 Levels in Metabolic Syndrome Patients After Low Calorie Diet), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06881706 nacompletednot on this mapstarted 2019, after this paper: background citation

Relationship Between Biochemical and Anthropometric Variables and CD36 Levels in Metabolic Syndrome Patients After Low Calorie Diet

TypeinterventionalSponsorOrdu UniversityRan2019 to 2020Enrolled65ConditionsMetabolic Syndrome, Weight LossArmsmedical nutrition therapy
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Circulating Liver-Derived and CD36Journal of extracellular vesicles · 2026
    Article
  2. CD36 and Its Role in Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jaco Botha1Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark.ORCID 0000-0002-8889-9959
Morten Hjuler Nielsen1Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark.
Maja Høegh Christensen1Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark.
Henrik Vestergaard3Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, SUND, University of Copenhagen, Panum, Mærsk tårnet, Bygning 7, 8. Etage, DK-2200 Copenhagen N, Denmark.
Aase Handberg1Department of Clinical Biochemistry, Aalborg University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark.
Aalborg University Hospital · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery is a widely adopted treatment for obesity and its secondary complications. In the past decade, microvesicles (MVs) and CD36 have increasingly been considered as possible biomarkers for obesity, the metabolic syndrome (MetSy), type 2 diabetes mellitus (T2DM). Thus, the purpose of this study was to investigate how weight loss resulting from bariatric surgery affects levels of specific MV phenotypes and their expression of CD36 scavenger receptor. Additionally, we hypothesised that subjects with MetSy had higher baseline concentrations of investigated MV phenotypes.

methodsTwenty individuals undergoing

resultsFollowing bariatric surgery, subjects incurred an average BMI reduction (delta) of - 8.4 ± 1.4 (

conclusionBariatric surgery resulted in significantly altered levels of CD36-bearing MVs of monocyte and endothelial origin. This likely reflects improvements in ectopic fat distribution, plasma lipid profile, low-grade inflammation, and oxidative stress following weight loss. Conversely, however, the presence of MetSy at baseline had no impact on MV phenotypes.

Indexed as

Bariatric surgeryCD36Ectopic fat depositionExtracellular vesiclesMetabolic syndromeObesity

Identifiers

PMID30386406
PMCPMC6199798
OpenAlexW2898036155

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.