Evidence map›Paper›PMID 30386348›Full record

ArticleFrontiers in immunology2018

Heterologous Immunization With Defined RNA and Subunit Vaccines Enhances T Cell Responses That Protect Against

Malcolm S Duthie, Neal Van Hoeven, Zachary MacMillen, Alessandro Picone, Raodoh Mohamath, Jesse Erasmus, Fan-Chi Hsu, Dan T Stinchcomb, Steven G Reed

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Design and Expression ofInternational journal of molecular sciences · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Advances inPathogens (Basel, Switzerland) · 2024
    Review
  12. Transmission-Blocking Vaccines against Schistosomiasis Japonica.International journal of molecular sciences · 2024
    Review
  13. Immunisation with TransgenicMicroorganisms · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Nanotechnology-based mRNA vaccines.Nature reviews. Methods primers · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Malcolm S DuthieInfectious Disease Research Institute, Seattle, WA, United States.
Neal Van HoevenInfectious Disease Research Institute, Seattle, WA, United States.
Zachary MacMillenInfectious Disease Research Institute, Seattle, WA, United States.
Alessandro PiconeInfectious Disease Research Institute, Seattle, WA, United States.
Raodoh MohamathInfectious Disease Research Institute, Seattle, WA, United States.
Jesse ErasmusInfectious Disease Research Institute, Seattle, WA, United States.
Fan-Chi HsuInfectious Disease Research Institute, Seattle, WA, United States.
Dan T StinchcombInfectious Disease Research Institute, Seattle, WA, United States.
Steven G ReedInfectious Disease Research Institute, Seattle, WA, United States.
Infectious Disease Research Institute · US

Funding

LEISHMANIA ANTIGENS DEFINES BY IMMUNE RESPONSESR01AI025038 · NIAID · SEATTLE BIOMEDICAL RESEARCH INSTITUTE · PI REED, STEVEN GREGORY · 1987 to 2016
$5.6M
Development of a novel replicating viral RNA vaccine platformF32AI136371 · NIAID · UNIVERSITY OF WASHINGTON · PI ERASMUS, JESSE HONG-SAE · 2018 to 2020
$165k
NIAID NIH HHS F32 AI136371NIAID NIH HHS HHSN272201600036CNIAID NIH HHS R01 AI025038
6 · The paper itself

Abstract

The rapid generation of strong T cell responses is highly desirable and viral vectors can have potent CD8

Indexed as

Immunity, HeterologousAnimalsCell LineCytokinesFemaleHumansImmunization, SecondaryLeishmania donovaniLeishmaniasis VaccinesLeishmaniasis, VisceralLymphocyte ActivationMiceNF-kappa BProtein TransportT-LymphocytesToll-Like Receptor 7CytokinesLeishmaniasis VaccinesNF-kappa BToll-Like Receptor 7Vaccines, SubunitVaccines, SyntheticadjuvantleishmaniaproteinRNAvaccine

Identifiers

PMID30386348
PMCPMC6199377
OpenAlexW2896883136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.