Evidence map›Paper›PMID 30386327›Full record

Trial reportFrontiers in immunology2018

Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly.

Sara Schaefer, Kasper Arthur Hettinga, James Cullor, J Bruce German, Bethany M Henrick

Erratum issuedOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sara SchaeferDepartment of Food Science and Technology, Foods for Health Institute, University of California, Davis, Davis, CA, United States.
Kasper Arthur HettingaWageningen University and Research, Wageningen, Netherlands.
James CullorDepartment of Food Science and Technology, Foods for Health Institute, University of California, Davis, Davis, CA, United States.
J Bruce GermanDepartment of Food Science and Technology, Foods for Health Institute, University of California, Davis, Davis, CA, United States.
Bethany M HenrickDepartment of Food Science and Technology, Foods for Health Institute, University of California, Davis, Davis, CA, United States.
University of California, Davis · USWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Protein nutrition has been shown to stimulate and strengthen the immune system, and such approaches are needed for this growing segment of the population. A controlled, randomized, double blind pilot study was conducted to compare two different protein sources (soy and dairy) as nutritional supplementation to enhance vaccine response. Our objective was to examine the immune stimulating effects of dairy protein subjected to ultraviolet radiation (UV-C) radiation treatment process instead of pasteurization. Participants were 21 healthy individuals over 60 years of age who consumed 6 g of the dairy protein or a comparison, soy isoflavone protein, twice a day for 8 weeks. DTaP vaccine administered at week 4. Non-parametric

Indexed as

AgedAnimalsAntibodies, BacterialDietary ProteinsDiphtheria-Tetanus-acellular Pertussis VaccinesDouble-Blind MethodHumansMiddle AgedMilkPilot ProjectsPowdersSoybean ProteinsTreatment OutcomeUltraviolet RaysAntibodies, BacterialDietary ProteinsDiphtheria-Tetanus-acellular Pertussis VaccinesPowdersSoybean Proteinsdairy proteinsimmune responsenutritional supplementationUV-C treatmentvaccines

Identifiers

PMID30386327
PMCPMC6200024
OpenAlexW2896391787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.