ReviewFrontiers in endocrinology2018
Understanding Ovarian Hypo-Response to Exogenous Gonadotropin in Ovarian Stimulation and Its New Proposed Marker-The Follicle-To-Oocyte (FOI) Index.
Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07632300 (Efficacy and Safety of Biphasic IVM in Low Prognosis Patients Classified as Poseidon Group 1A), which is not on this map. Cited by 102 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Safety of Biphasic IVM in Low Prognosis Patients Classified as Poseidon Group 1A
Who cites it
102 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effect of ESR1 and ESR2 polymorphisms on ovarian response in assisted reproductive technology cycles: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Systematic review of acupuncture to improve ovarian function in women with poor ovarian response.Frontiers in endocrinology · 2023Pooled it
- Dose adjustment of follicle-stimulating hormone (FSH) during ovarian stimulation as part of medically-assisted reproduction in clinical studies: a systematic review covering 10 years (2007-2017).Reproductive biology and endocrinology : RB&E · 2021Pooled it
- The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2019Pooled it
- The impact of resveratrol on the outcome of the in vitro fertilization: an exploratory randomized placebo-controlled trial.Journal of ovarian research · 2024Trial
- The comparison of two different protocols ultra-long versus medroxyprogesterone acetate in women with ovarian endometriosis: a prospective randomized controlled trial.Reproductive health · 2022Trial
- Luteinizing hormone-based modified GnRH antagonist protocol in normal responders undergoingFrontiers in endocrinology · 2022Trial
- Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats.International journal of molecular sciences · 2021Trial
- Step-Down of FSH- Dosage During Ovarian Stimulation - Basic Lessons to Be Learnt From a Randomized Controlled Trial.Frontiers in endocrinology · 2021Trial
- Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging.Research square · 2026Article
- The Oocyte/Antral Follicle Count Index: Does Maximizing Oocyte Yield Translate Into Better Assisted Reproductive Technology Outcomes?Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Clinical outcomes of the short agonist stop protocol versus the long GnRH agonist protocol in poor ovarian responders undergoing IVF/ICSI: a retrospective analysis.BMC pregnancy and childbirth · 2026Article
- Controlled Ovarian Stimulation Outcomes Across Different Malignancies in Women Undergoing Fertility Preservation: The Role of AMH and AFC in Predicting Ovarian Response.Journal of clinical medicine · 2026Article
- Evaluating the role of follicular output rate in clinical and embryological outcomes in IVF: a prospective study.Archives of gynecology and obstetrics · 2026Article
- Association between menstrual cycle length and ovarian reserve markers and stimulation response: a retrospective cohort study.BMC women's health · 2026Article
- IGF-1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Optimizing family building in women of advanced reproductive age: a Faster-Fewer-and-Finished approach.Frontiers in endocrinology · 2026Review
- Assessment indicators of ovarian response during controlled ovarian stimulation: influencing factors and clinical value.Frontiers in endocrinology · 2026Review
- Luteinizing hormone dynamics during progestin-primed ovarian stimulation do not predict follicular output in women with normo-ovarian reserve.Frontiers in endocrinology · 2026Article
- Effects of different seasons on the outcome ofFrontiers in reproductive health · 2026Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypo-responsiveness to controlled ovarian stimulation is an undervalued topic in reproductive medicine. This phenomenon manifests as a low follicles output rate (FORT) with a discrepancy between the relatively low number of pre-ovulatory follicles which develop following ovarian stimulation as compared to the number of antral follicles available at the start of stimulation. The pathophysiology mechanisms explaining the ovarian resistance to gonadotropin stimulation are not fully understood, but the fact that both hypo-responders and normal responders share similar phenotypic characteristics suggests a genotype-based mechanism. Indeed, existing evidence supports the association between specific gonadotropin and their receptor polymorphisms and ovarian hypo-response. Apart from genotypic trait, environmental contaminants and oxidative stress might also be involved in the hypo-response pathogenesis. The ratio between the number of oocytes collected at the ovum pick up and the number of antral follicles at the beginning of OS [Follicle to oocyte index (FOI)] is proposed as a novel parameter to assess the hypo-response. Compared with traditional ovarian reserve markers, FOI might reflect most optimally the dynamic nature of follicular growth in response to exogenous gonadotropin. In this review, we contextualize the role of FOI as a parameter to identify this condition, discuss the underlying mechanisms potentially implicated in the pathogenesis of hypo-response, and appraise possible the treatment strategies to overcome hyper-responsiveness to gonadotropin stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.