ArticleFrontiers in physiology2018
Muscle Adaptations to High-Load Training and Very Low-Load Training With and Without Blood Flow Restriction.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06413199 (Adaptive Response of Brain Towards Resistance Training in Healthy Individuals), which is not on this map. Cited by 58 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adaptive Response of Brain Towards Resistance Training in Healthy Individuals
Who cites it
58 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Non-Specific Strength Changes Between High- and Low-Load Isotonic Resistance Training: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Comparing adaptations from blood flow restriction exercise training using regulated or unregulated pressure systems: A systematic review and meta-analysis.Clinical rehabilitation · 2024Pooled it
- Potential Moderators of the Effects of Blood Flow Restriction Training on Muscle Strength and Hypertrophy: A Meta-analysis Based on a Comparison with High-Load Resistance Training.Sports medicine - open · 2024Pooled it
- Effects of Chronic Static Stretching on Maximal Strength and Muscle Hypertrophy: A Systematic Review and Meta-Analysis with Meta-Regression.Sports medicine - open · 2024Pooled it
- Quantifying the Generality of Strength Adaptation: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Pooled it
- Is There a Minimum Effective Dose for Vascular Occlusion During Blood Flow Restriction Training?Frontiers in physiology · 2022Pooled it
- A Systematic Review and Meta-Analysis on Neural Adaptations Following Blood Flow Restriction Training: What We Know and What We Don't Know.Frontiers in physiology · 2020Pooled it
- Blood flow restriction as an adjunct during mid-stage rehabilitation after ACL reconstruction: a randomized sham-controlled study.BMC musculoskeletal disorders · 2026Trial
- Submaximal low-load resistance exercise with blood flow restriction produces similar results to low-load exercise to failure for muscle size and strength, but not endurance.European journal of applied physiology · 2026Trial
- Post activation potentiation effect of different preloading protocols on sprint performance.Scientific reports · 2025Trial
- Effects of Blood Flow Restriction Resistance Exercise Versus Traditional Resistance Exercise in Voluntary Exhaustion on Quadriceps Muscle Adaptations in Untrained Young Males: A Randomized Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- The impact of acute blood-flow-restriction resistance exercise on somatosensory-evoked potentials in healthy adults.Experimental physiology · 2024Trial
- Trial
- A Retrospective Analysis to Determine Whether Training-Induced Changes in Muscle Thickness Mediate Changes in Muscle Strength.Sports medicine (Auckland, N.Z.) · 2021Trial
- Blood Flow Restriction Only Increases Myofibrillar Protein Synthesis with Exercise.Medicine and science in sports and exercise · 2019Trial
- Can Resistance Training-Induced Skeletal Muscle Growth Improve Local Muscular Endurance?Sports medicine (Auckland, N.Z.) · 2026Review
- Analytical approaches to account for muscle size when evaluating strength.European journal of applied physiology · 2026Review
- Effects of low-load blood flow restriction vs. high-load resistance training on upper-body strength in male collegiate gymnasts: A randomized controlled trial.Journal of exercise science and fitness · 2026Article
- Cardiorespiratory and vascular function outcomes following 4 weeks of single-sprint training.Frontiers in physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An inability to lift loads great enough to disrupt muscular blood flow may impair the ability to fatigue muscles, compromising the hypertrophic response. It is unknown what level of blood flow restriction (BFR) pressure, if any, is necessary to reach failure at very low-loads [i.e., 15% one-repetition maximum (1RM)]. The purpose of this study was to investigate muscular adaptations following resistance training with a very low-load alone (15/0), with moderate BFR (15/40), or with high BFR (15/80), and compare them to traditional high-load (70/0) resistance training. Using a within/between subject design, healthy young participants (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.