ArticleFrontiers in aging neuroscience2018
Smaller Hippocampal Volume and Degraded Peripheral Hearing Among Japanese Community Dwellers.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: A systematic review and meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Alzheimer's disease biomarkers in relation to non-cognitive domains within the intrinsic capacity framework: a narrative review.GeroScience · 2026Review
- Brain morphological changes in acquired hearing loss: A surface-based morphometry study.PloS one · 2026Article
- Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.Scientific reports · 2025Article
- Hearing Loss, Brain Structure, Cognition, and Dementia Risk in the Framingham Heart Study.JAMA network open · 2025Article
- Brain structural reorganization mediates the relationship between hearing loss and cognitive impairment.Brain imaging and behavior · 2025Article
- A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study.Journal of otology · 2025Article
- Longitudinal relationships between daily activity and hippocampal atrophy in Japanese dwellers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Dissecting the Interactions of Diabetes Mellitus and Hearing Loss with Cognitive Decline and Dementia.Brain sciences · 2025Review
- Isoflavone intake is associated with longitudinal changes in hippocampal volume, but not total grey matter volume, in Japanese middle-aged and older community dwellers.European journal of nutrition · 2025Article
- Brain volumetric analysis of elderly patients based on hearing levels quantified using FreeSurfer.Frontiers in neurology · 2025Article
- Normal hearing function genetics: have you heard all about it? An integrated approach of genome-wide association studies and transcriptome-wide association studies in three Italian cohorts.Frontiers in genetics · 2025Article
- Evidence of functional connectivity disruptions between auditory and non-auditory regions in adolescents living with HIV.Frontiers in systems neuroscience · 2025Article
- Association between widowhood and cognitive function among Chinese older adults with hearing impairment: the moderating effect of social support and participation.BMC geriatrics · 2024Article
- Associations of dietary patterns and longitudinal brain-volume change in Japanese community-dwelling adults: results from the national institute for longevity sciences-longitudinal study of aging.Nutrition journal · 2024Article
- What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?Human brain mapping · 2024Review
- Hippocampal atrophy is associated with hearing loss in cognitively normal adults.Frontiers in neuroscience · 2023Article
- Elevated Pure Tone Thresholds Are Associated with Altered Microstructure in Cortical Areas Related to Auditory Processing and Attentional Allocation.Journal of Alzheimer's disease : JAD · 2023Article
- Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology.EBioMedicine · 2022Article
- Longitudinal Changes in Resting-State Functional Connectivity and Gray Matter Volume Are Associated with Conversion to Hearing Impairment in Older Adults.Journal of Alzheimer's disease : JAD · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of literature has demonstrated that dementia and hearing loss are interrelated. Recent interest in dementia research has expanded to brain imaging analyses with auditory function. The aim of this study was to investigate the link between hearing ability, which was assessed using pure-tone audiometry, and the volume of brain regions, specifically the hippocampus, entorhinal cortex, Heschl's gyrus, and total gray matter, using Freesurfer software and T1-weighted brain magnetic resonance imaging. The data for 2082 samples (age range = 40-89 years) were extracted from a population-based cohort of community dwellers. Hearing-impaired individuals showed significantly smaller hippocampal volumes compared with their non-hearing-impaired counterparts for all auditory frequency ranges. In addition, a correlational analysis showed a significant dose-response relationship for hearing ability and hippocampal volume after adjusting for potential confounding factors so that the more degraded the peripheral hearing was, the smaller the hippocampal volume was. This association was consistent through the auditory frequency range. The volume of the entorhinal cortex, right Heschl's gyrus and total gray matter did not correlate with hearing level at any frequency. The volume of the left Heschl's gyrus showed a significant relationship with the hearing levels for some auditory frequencies. The current results suggested that the presence of hearing loss after middle age could be a modifier of hippocampal atrophy.
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