Evidence map›Paper›PMID 30386216›Full record

ArticleFrontiers in neural circuits2018

VAST (Volume Annotation and Segmentation Tool): Efficient Manual and Semi-Automatic Labeling of Large 3D Image Stacks.

Daniel R Berger, H Sebastian Seung, Jeff W Lichtman

Abstract read
In one paragraph

Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed.

  1. Article
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  6. RAEM: random-access electron microscopy for revisitable 3D imaging.bioRxiv : the preprint server for biology · 2026
    Article
  7. FEABAS: A Stitching and Alignment Tool for Serial EM Data.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. TriSAM: Tri-Plane SAM for Zero-Shot Cortical Blood Vessel Segmentation in VEM Images.IEEE journal of biomedical and health informatics · 2025
    Article
  17. Article
  18. Article
  19. Emergence of Functional Heart-Brain Circuits in a Vertebrate.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel R BergerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, United States.
H Sebastian SeungComputer Science Department, Princeton Neuroscience Institute, Princeton University, Princeton, NJ, United States.
Jeff W LichtmanDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, United States.

Funding

Zooming into the fish's brain-What is really going on! Connectomics analysis of larval zebrafish.U19NS104653 · NINDS · HARVARD UNIVERSITY · PI Jeff W Lichtman · 2017 to 2026
$39.4M
Res Support CoreP50MH094271 · NIMH · HARVARD UNIVERSITY · PI HENSCH, TAKAO K · 2011 to 2022
$18.6M
Howard Hughes Medical InstituteNIMH NIH HHS P50 MH094271NINDS NIH HHS U19 NS104653
6 · The paper itself

Abstract

Recent developments in serial-section electron microscopy allow the efficient generation of very large image data sets but analyzing such data poses challenges for software tools. Here we introduce Volume Annotation and Segmentation Tool (VAST), a freely available utility program for generating and editing annotations and segmentations of large volumetric image (voxel) data sets. It provides a simple yet powerful user interface for real-time exploration and analysis of large data sets even in the Petabyte range.

Indexed as

SoftwareAlgorithmsConnectomeDatabases, FactualHumansImage Processing, Computer-AssistedImaging, Three-DimensionalMicroscopy, ElectronNeuronsCLEMconnectomicsproofreadingsegmentationserial section electron microscopyTrakEM2visualizationvoxel

Identifiers

PMID30386216
PMCPMC6198149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.